DO264
- $73 - $2400
- Product name: DO264
- CAS: 2301866-59-9
- MF: C23H20Cl2F3N5O2S
- MW: 558.4
- EINECS:604-604-1
- MDL Number:MFCD31812603
- Synonyms:N-[1-[3-Chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinylthiourea;Thiourea, N-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinyl-;DO264;DO-264;DO 264;DO264 (DO-264;DO264
10 prices
Selected condition:
Brand
- AK Scientific
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 1g
- ManufacturerAK Scientific
- Product number8011EL
- Product descriptionCID134813646
- Packaging1mg
- Price$179
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2982
- Product descriptionDO264 99%
- Packaging25mg
- Price$511.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBD167529
- Product descriptionDO 264
- Packaging10mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBD167529
- Product descriptionDO 264
- Packaging50mg
- Price$472.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29402
- Product descriptionDO264
- Packaging1mg
- Price$73
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29402
- Product descriptionDO264
- Packaging5mg
- Price$324
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29402
- Product descriptionDO264
- Packaging10mg
- Price$575
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0077182
- Product descriptionDO-264 98.81%
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0077182
- Product descriptionDO-264 98.81%
- Packaging10mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC11464
- Product descriptionDO-264 >98%
- Packaging1g
- Price$2400
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 8011EL | CID134813646 | 1mg | $179 | 2021-12-16 | Buy |
Axon Medchem | Axon2982 | DO264 99% | 25mg | $511.5 | 2021-12-16 | Buy |
Biosynth Carbosynth | BD167529 | DO 264 | 10mg | $135 | 2021-12-16 | Buy |
Biosynth Carbosynth | BD167529 | DO 264 | 50mg | $472.5 | 2021-12-16 | Buy |
Cayman Chemical | 29402 | DO264 | 1mg | $73 | 2024-03-01 | Buy |
Cayman Chemical | 29402 | DO264 | 5mg | $324 | 2024-03-01 | Buy |
Cayman Chemical | 29402 | DO264 | 10mg | $575 | 2024-03-01 | Buy |
ChemScene | CS-0077182 | DO-264 98.81% | 5mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-0077182 | DO-264 98.81% | 10mg | $250 | 2021-12-16 | Buy |
DC Chemicals | DC11464 | DO-264 >98% | 1g | $2400 | 2021-12-16 | Buy |
Properties
Boiling point :601.5±65.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml).
form :solid
pka :11.53±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml).
form :solid
pka :11.53±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
Symbol(GHS): | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | |||||||||||||||||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
DO264 is an inhibitor of α/β-hydrolase domain-containing protein 12 (ABHD12; IC50 = 11 nM). It inhibits ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells. DO264 increases levels of chemokine (C-C motif) ligand 3 (CCL3), CCL4, TNF-α, and IL-1β in M1-polarized THP-1 macrophages. It potentiates ferroptotic cell death induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in HT1080 fibrosarcoma and SU-DHL-5 B cell lymphoma cells when used at a concentration of 1 μM. In vivo, DO264 (30 mg/kg per day for four weeks) increases levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PS, 1-arachidonoyl-2-hydroxy-sn-glycero-3-PS, 1-docosanoyl-2-hydroxy-sn-glycero-3-PS, 1-stearoyl-2-arachidonoyl-sn-glycero-3-PS, and 1-oleoyl-2-arachidonoyl-sn-glycero-3-PS in mouse brain. It increases levels of CCL2, CCL3, and CCL5 in bronchoalveolar lavage fluid (BALF) and decreases survival in a mouse model of infection with lymphocytic choriomeningitis virus (LCMV) clone 13 when administered at a dose of 30 mg/kg.Related product price
- N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1)
$79-8853.08 - Levetiracetam
$5-1504.5 - AZ20
$25-1900
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Career Henan Chemica Co
Zhejiang J&C Biological Technology Co.,Limited
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai EFE Biological Technology Co., Ltd.
ShangHai Biochempartner Co.,Ltd
Chuzhou KeMail Chemical Technology Co., Ltd