EI1
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- $37 - $2600
- Product name: EI1
- CAS: 1418308-27-6
- MF: C23H26N4O2
- MW: 390.48
- EINECS:
- MDL Number:MFCD25976740
- Synonyms:EI1;Ezh2 inhibitor;6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide;EI1;EI-1;EI 1;6-cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide;CS-2378;EI1 (Ezh2 inhibitor;EI1;EI 1
18 prices
Selected condition：
Brand
- Ambeed
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 1mg
- 25mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- 5mg
- 10mg
- 50mg
- 100mg
- ManufacturerAmbeed
- Product numberA163218
- Product descriptionEI1 98+%
- Packaging5mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA163218
- Product descriptionEI1 98+%
- Packaging10mg
- Price$305
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA163218
- Product descriptionEI1 98+%
- Packaging50mg
- Price$514
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA163218
- Product descriptionEI1 98+%
- Packaging100mg
- Price$667
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1021
- Product descriptionEI1
- Packaging10mM(in 1mL DMSO)
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1021
- Product descriptionEI1
- Packaging25mg
- Price$335
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19146
- Product descriptionEI1 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19146
- Product descriptionEI1 ≥98%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19146
- Product descriptionEI1 ≥98%
- Packaging10mg
- Price$213
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM147358
- Product description6-cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide 95%+
- Packaging100mg
- Price$530
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1654
- Product descriptionEI1 99.18%
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1654
- Product descriptionEI1 99.18%
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1654
- Product descriptionEI1 99.18%
- Packaging50mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1654
- Product descriptionEI1 99.18%
- Packaging100mg
- Price$695
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003557
- Product descriptionEI1 98+%
- Packaging100mg
- Price$920
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7930
- Product descriptionEI-1 >98%
- Packaging250mg
- Price$1430
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A163218 | EI1 98+% | 5mg | $235 | 2021-12-16 | Buy |
| Ambeed | A163218 | EI1 98+% | 10mg | $305 | 2021-12-16 | Buy |
| Ambeed | A163218 | EI1 98+% | 50mg | $514 | 2021-12-16 | Buy |
| Ambeed | A163218 | EI1 98+% | 100mg | $667 | 2021-12-16 | Buy |
| ApexBio Technology | B1021 | EI1 | 10mM(in 1mL DMSO) | $130 | 2021-12-16 | Buy |
| ApexBio Technology | B1021 | EI1 | 25mg | $335 | 2021-12-16 | Buy |
| Cayman Chemical | 19146 | EI1 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19146 | EI1 ≥98% | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 19146 | EI1 ≥98% | 10mg | $213 | 2024-03-01 | Buy |
| Chemenu | CM147358 | 6-cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide 95%+ | 100mg | $530 | 2021-12-16 | Buy |
| ChemScene | CS-1654 | EI1 99.18% | 5mg | $95 | 2021-12-16 | Buy |
| ChemScene | CS-1654 | EI1 99.18% | 10mg | $160 | 2021-12-16 | Buy |
| ChemScene | CS-1654 | EI1 99.18% | 50mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-1654 | EI1 99.18% | 100mg | $695 | 2021-12-16 | Buy |
| Crysdot | CD31003557 | EI1 98+% | 100mg | $920 | 2021-12-16 | Buy |
| DC Chemicals | DC7930 | EI-1 >98% | 250mg | $1430 | 2021-12-16 | Buy |
Properties
Boiling point :675.9±55.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥19.5 mg/mL in DMSO
form :Powder
pka :11.88±0.10(Predicted)
color :White to off-white
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥19.5 mg/mL in DMSO
form :Powder
pka :11.88±0.10(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 on histone H3 (H3K27) and is involved in proliferation and aggressive cell growth associated with neoplastic cells. EI1 is an EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC50s = 15 and 13 nM, respectively). It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold over other lysine methyltransferases. EI1 blocks cellular H3K27 methylation and activates PRC2-specific gene expression. Inhibition of EZH2 by EI1 in diffused large B cell lymphoma cells carrying Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis.Related product price
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