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ChemicalBook >> CAS DataBase List >> EPZ011969

EPZ011969

EPZ011969 price.
  • $60 - $1932
  • Product name: EPZ011969
  • CAS: 1598383-40-4
  • MF: C35H51N5O4
  • MW: 605.81
  • EINECS:-0
  • MDL Number:MFCD28964159
  • Synonyms:EPZ011969;EPZ011989;N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]benzamide;N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-ynyl)benzamide;EPZ011989;EPZ-011989;CS-2079;CS-1609;N-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-3-(ETHYL((TRANS)-4-((2-METHOXYETHYL)(METHYL)AMINO)CYCLOHEXYL)AMINO)-2-METHYL-5-(3-MORPHOLINOPROP-1-YN-1-YL)BENZAMIDE
17 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • TRC
  • Usbiological
Package
  • 500μg
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number7558DW
  • Product descriptionCID73670548
  • Packaging10mg
  • Price$286
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number7558DW
  • Product descriptionCID73670548
  • Packaging50mg
  • Price$876
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0002501
  • Product descriptionEPZ011989 95.00%
  • Packaging5MG
  • Price$497.54
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFE137669
  • Product descriptionEPZ 011989
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFE137669
  • Product descriptionEPZ 011989
  • Packaging50mg
  • Price$612.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19161
  • Product descriptionEPZ011989 ≥98%
  • Packaging500μg
  • Price$120
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19161
  • Product descriptionEPZ011989 ≥98%
  • Packaging1mg
  • Price$228
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19161
  • Product descriptionEPZ011989 ≥98%
  • Packaging5mg
  • Price$952
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4592
  • Product descriptionEPZ011989 99.62%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4592
  • Product descriptionEPZ011989 99.62%
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4592
  • Product descriptionEPZ011989 99.62%
  • Packaging50mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4592
  • Product descriptionEPZ011989 99.62%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
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  • ManufacturerDC Chemicals
  • Product numberDC7927
  • Product descriptionEPZ011989 >98%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7927
  • Product descriptionEPZ011989 >98%
  • Packaging250mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7927
  • Product descriptionEPZ011989 >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD450170
  • Product descriptionN-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-benzamide
  • Packaging25mg
  • Price$110
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 7558DW CID73670548 10mg $286 2021-12-16 Buy
AK Scientific 7558DW CID73670548 50mg $876 2021-12-16 Buy
American Custom Chemicals Corporation KIN0002501 EPZ011989 95.00% 5MG $497.54 2021-12-16 Buy
Biosynth Carbosynth FE137669 EPZ 011989 10mg $175 2021-12-16 Buy
Biosynth Carbosynth FE137669 EPZ 011989 50mg $612.5 2021-12-16 Buy
Cayman Chemical 19161 EPZ011989 ≥98% 500μg $120 2024-03-01 Buy
Cayman Chemical 19161 EPZ011989 ≥98% 1mg $228 2024-03-01 Buy
Cayman Chemical 19161 EPZ011989 ≥98% 5mg $952 2024-03-01 Buy
ChemScene CS-4592 EPZ011989 99.62% 5mg $60 2021-12-16 Buy
ChemScene CS-4592 EPZ011989 99.62% 10mg $90 2021-12-16 Buy
ChemScene CS-4592 EPZ011989 99.62% 50mg $280 2021-12-16 Buy
ChemScene CS-4592 EPZ011989 99.62% 100mg $450 2021-12-16 Buy
DC Chemicals DC7927 EPZ011989 >98% 100mg $450 2021-12-16 Buy
DC Chemicals DC7927 EPZ011989 >98% 250mg $800 2021-12-16 Buy
DC Chemicals DC7927 EPZ011989 >98% 1g $1800 2021-12-16 Buy
TRC D450170 N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-benzamide 25mg $110 2021-12-16 Buy

Properties

Boiling point :756.7±60.0 °C(Predicted)
Density :1.17±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:55.0(Max Conc. mg/mL);90.79(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);16.51(Max Conc. mM)
Ethanol:60.0(Max Conc. mg/mL);99.04(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.83(Max Conc. mM) form :A crystalline solid
pka :11.88±0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells. EPZ011989 is an orally bioavailable EZH2 inhibitor with Ki values that are less than 3 nM for wild type and Tyr646 mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an array of other lysine methyltransferases. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.