ETP46464
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- $37 - $2691.1
- Product name: ETP46464
- CAS: 1345675-02-6
- MF: C30H22N4O2
- MW: 470.52
- EINECS:-0
- MDL Number:MFCD23160051
- Synonyms:Benzeneacetonitrile, α,α-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-;alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile ETP46464;2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile;ETP46464;alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile;2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl);ETP 46464; ETP46464;ETP46464 USP/EP/BP
27 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 1000mg
- ManufacturerAK Scientific
- Product number2406AH
- Product description2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl)propanenitrile
- Packaging50mg
- Price$1629
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8626
- Product descriptionETP-46464
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180984
- Product descriptionETP-46464 >98%
- Packaging100mg
- Price$838.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180984
- Product descriptionETP-46464 >98%
- Packaging250mg
- Price$1431.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180984
- Product descriptionETP-46464 >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19809
- Product descriptionETP-46464 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19809
- Product descriptionETP-46464 ≥98%
- Packaging5mg
- Price$134
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19809
- Product descriptionETP-46464 ≥98%
- Packaging10mg
- Price$249
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-1683
- Product descriptionETP-46464 98.01%
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1683
- Product descriptionETP-46464 98.01%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1683
- Product descriptionETP-46464 98.01%
- Packaging50mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1683
- Product descriptionETP-46464 98.01%
- Packaging100mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003815
- Product descriptionETP-46464 98+%
- Packaging5mg
- Price$78
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003815
- Product descriptionETP-46464 98+%
- Packaging10mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003815
- Product descriptionETP-46464 98+%
- Packaging50mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003815
- Product descriptionETP-46464 98+%
- Packaging100mg
- Price$732
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2406AH | 2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl)propanenitrile | 50mg | $1629 | 2021-12-16 | Buy |
| ApexBio Technology | A8626 | ETP-46464 | 10mg | $150 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180984 | ETP-46464 >98% | 100mg | $838.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180984 | ETP-46464 >98% | 250mg | $1431.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180984 | ETP-46464 >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Cayman Chemical | 19809 | ETP-46464 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19809 | ETP-46464 ≥98% | 5mg | $134 | 2024-03-01 | Buy |
| Cayman Chemical | 19809 | ETP-46464 ≥98% | 10mg | $249 | 2024-03-01 | Buy |
| ChemScene | CS-1683 | ETP-46464 98.01% | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-1683 | ETP-46464 98.01% | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-1683 | ETP-46464 98.01% | 50mg | $500 | 2021-12-16 | Buy |
| ChemScene | CS-1683 | ETP-46464 98.01% | 100mg | $900 | 2021-12-16 | Buy |
| Crysdot | CD31003815 | ETP-46464 98+% | 5mg | $78 | 2021-12-16 | Buy |
| Crysdot | CD31003815 | ETP-46464 98+% | 10mg | $130 | 2021-12-16 | Buy |
| Crysdot | CD31003815 | ETP-46464 98+% | 50mg | $500 | 2021-12-16 | Buy |
| Crysdot | CD31003815 | ETP-46464 98+% | 100mg | $732 | 2021-12-16 | Buy |
Properties
Boiling point :709.3±60.0 °C(Predicted)
Density :1.310±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥16.13 mg/mL in DMSO
form :solid
pka :5.10±0.20(Predicted)
color :Light yellow to yellow
Density :1.310±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥16.13 mg/mL in DMSO
form :solid
pka :5.10±0.20(Predicted)
color :Light yellow to yellow
Safety Information
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Description
ETP-46464 is an inhibitor of the DNA damage response kinase Ataxia-telangiectasia mutated (ATM)- and Rad3-related (ATR) with an IC50 value of 25 nM. It also inhibits mTOR and DNA-dependent protein kinase (IC50s = 0.6 and 36 nM, respectively), and is moderately active against PI3Kα and ATM (IC50s = 170 and 545 nM, respectively). Pharmacological inhibition of ATR is reported to generate replicative stress, leading to chromosomal breakage in the presence of conditions that stall replication forks. ETP-46464 has been shown to be toxic to p53-deficient cells, which is exacerbated by replicative stress-generating conditions such as the overexpression of cyclin E.Related product price
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