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ChemicalBook >> CAS DataBase List >> FK-506-13C-d2

FK-506-13C-d2

FK-506-13C-d2 price.
  • $520 - $1850
  • Product name: FK-506-13C-d2
  • CAS: 1356841-89-8
  • MF: C44H67D2NO12
  • MW: 807.039483556
  • EINECS:
  • MDL Number:MFCD31808174
  • Synonyms:(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-13C-d2)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone;Tacrolimus-13C;Tacrolimus-13C,D2 solution;TACROLIMUS (13C, 99%;FK-506-13C,D2 (Major) (Tacrolimus) (>(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-13C-d2)-;FK-506-13C,D2 (Major) (Tacrolimus)(>85%);D2, 98%) 100 UG/ML IN ACETONITRILE
Price4 Properties Safety Information Description
4 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • TRC
Package
  • 1mg
  • 2.5mg
  • 500 μg
  • ManufacturerAK Scientific
  • Product number2276EL
  • Product description(1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-(3,3-Dideuterio(313C)prop-2-enyl)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
  • Packaging1mg
  • Price$1178
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22178
  • Product descriptionFK-506-13C-d2 ≥99% deuterated forms (d1-d2); ≤1% d0
  • Packaging500 μg
  • Price$520
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22178
  • Product descriptionFK-506-13C-d2 ≥99% deuterated forms (d1-d2); ≤1% d0
  • Packaging1mg
  • Price$863
  • Updated2022-04-27
  • Buy
  • ManufacturerTRC
  • Product numberF370002
  • Product descriptionFK-506-13C,D2(Major)(Tacrolimus)(>85%)
  • Packaging2.5mg
  • Price$1850
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2276EL (1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-(3,3-Dideuterio(313C)prop-2-enyl)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone 1mg $1178 2021-12-16 Buy
Cayman Chemical 22178 FK-506-13C-d2 ≥99% deuterated forms (d1-d2); ≤1% d0 500 μg $520 2024-03-01 Buy
Cayman Chemical 22178 FK-506-13C-d2 ≥99% deuterated forms (d1-d2); ≤1% d0 1mg $863 2022-04-27 Buy
TRC F370002 FK-506-13C,D2(Major)(Tacrolimus)(>85%) 2.5mg $1850 2021-12-16 Buy

Properties

storage temp. :-70°C
solubility :Chloroform: Slightly Soluble,Methanol: Slightly Soluble
form :A solid
color :White to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

FK-506-13C-d2 contains two deuterium atoms located on the carbon-13 bond. It is intended for use as an internal standard for the quantification of FK-506 by GC- or LC-MS. FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation. The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors. In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3 receptors which can be disrupted by FK-506, thereby rendering the receptors “leaky” to Ca2+.

Suppliers and manufacturers

SIMSON PHARMA LIMITED
Tacrolimus-13C,D2
$0.00 /25mg
Tacrolimus-13C,D2 CAS:1356841-89-8
Shanghai Kewel Chemical Co., Ltd. Sigma-Aldrich Artis Biotech Co. Ltd. Shanghai EFE Biological Technology Co., Ltd. ChemeGen(Shanghai) Biotechnology Co.,Ltd. Cato Research Chemicals Inc. Nanjing Shizhou Biology Technology Co.,Ltd Energy Chemical QUALITY CONTROL SOLUTIONS LTD.