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ChemicalBook >> CAS DataBase List >> GSK-J4 Hydrochloride

GSK-J4 Hydrochloride

GSK-J4 Hydrochloride price.
  • $25 - $1624
  • Product name: GSK-J4 Hydrochloride
  • CAS: 1797983-09-5
  • MF: C24H28ClN5O2
  • MW: 453.96442
  • EINECS:
  • MDL Number:MFCD26142638
  • Synonyms:GSK-J4 Hydrochloride ;TYXWLTBYINKVNT-UHFFFAOYSA-N;Ethyl N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alaninate hydrochloride;1797983-09-5 (HCl);Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate hydrochloride;Histone Demethylase,diabetic,Th17,mice,cells,inflammation,Th1,H3K27me3/me2,dendritic,GSKJ4 Hydrochloride,TGF-β,inhibit,Inhibitor,GSK J4 Hydrochloride,demethylase,GSK-J4,GSK-J-4 Hydrochloride
Price23 Properties Safety Information Description
23 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • Arctom
  • Cayman Chemical
  • ChemScene
  • CSNpharm
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2915DV
  • Product descriptionGSKJ4HCl
  • Packaging25mg
  • Price$173
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2915DV
  • Product descriptionGSKJ4HCl
  • Packaging1g
  • Price$1624
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA608057
  • Product descriptionGSK-J4Hydrochloride 98+%
  • Packaging10mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA608057
  • Product descriptionGSK-J4Hydrochloride 98+%
  • Packaging25mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA608057
  • Product descriptionGSK-J4Hydrochloride 98+%
  • Packaging50mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA608057
  • Product descriptionGSK-J4Hydrochloride 98+%
  • Packaging100mg
  • Price$233
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA608057
  • Product descriptionGSK-J4Hydrochloride 98+%
  • Packaging250mg
  • Price$466
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA608057
  • Product descriptionGSK-J4Hydrochloride 98+%
  • Packaging1g
  • Price$1364
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS611874
  • Product descriptionGSK-J4Hydrochloride ≥98%
  • Packaging10mg
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS611874
  • Product descriptionGSK-J4Hydrochloride ≥98%
  • Packaging25mg
  • Price$83
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS611874
  • Product descriptionGSK-J4Hydrochloride ≥98%
  • Packaging50mg
  • Price$134
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS611874
  • Product descriptionGSK-J4Hydrochloride ≥98%
  • Packaging100mg
  • Price$231
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS611874
  • Product descriptionGSK-J4Hydrochloride ≥98%
  • Packaging250mg
  • Price$461
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS611874
  • Product descriptionGSK-J4Hydrochloride ≥98%
  • Packaging1g
  • Price$1147
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number12073
  • Product descriptionGSK-J4 (hydrochloride) ≥95%
  • Packaging1mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number12073
  • Product descriptionGSK-J4 (hydrochloride) ≥95%
  • Packaging5mg
  • Price$57
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2915DV GSKJ4HCl 25mg $173 2021-12-16 Buy
AK Scientific 2915DV GSKJ4HCl 1g $1624 2021-12-16 Buy
Ambeed A608057 GSK-J4Hydrochloride 98+% 10mg $53 2021-12-16 Buy
Ambeed A608057 GSK-J4Hydrochloride 98+% 25mg $84 2021-12-16 Buy
Ambeed A608057 GSK-J4Hydrochloride 98+% 50mg $135 2021-12-16 Buy
Ambeed A608057 GSK-J4Hydrochloride 98+% 100mg $233 2021-12-16 Buy
Ambeed A608057 GSK-J4Hydrochloride 98+% 250mg $466 2021-12-16 Buy
Ambeed A608057 GSK-J4Hydrochloride 98+% 1g $1364 2021-12-16 Buy
Arctom AS611874 GSK-J4Hydrochloride ≥98% 10mg $52 2021-12-16 Buy
Arctom AS611874 GSK-J4Hydrochloride ≥98% 25mg $83 2021-12-16 Buy
Arctom AS611874 GSK-J4Hydrochloride ≥98% 50mg $134 2021-12-16 Buy
Arctom AS611874 GSK-J4Hydrochloride ≥98% 100mg $231 2021-12-16 Buy
Arctom AS611874 GSK-J4Hydrochloride ≥98% 250mg $461 2021-12-16 Buy
Arctom AS611874 GSK-J4Hydrochloride ≥98% 1g $1147 2021-12-16 Buy
Cayman Chemical 12073 GSK-J4 (hydrochloride) ≥95% 1mg $25 2021-12-16 Buy
Cayman Chemical 12073 GSK-J4 (hydrochloride) ≥95% 5mg $57 2024-03-01 Buy
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Properties

storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :DMSO:60.83(Max Conc. mg/mL);134.0(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:7):0.1(Max Conc. mg/mL);0.22(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);66.08(Max Conc. mM)
Ethanol:55.0(Max Conc. mg/mL);121.15(Max Conc. mM)
Water:10.0(Max Conc. mg/mL);22.03(Max Conc. mM) form :A crystalline solid
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H290 May be corrosive to metals Corrosive to Metals Category 1 Warning GHS hazard pictograms P234, P390, P404
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P234 Keep only in original container.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363 Wash contaminated clothing before reuse.
P390 Absorb spillage to prevent material damage.
P405 Store locked up.
P406 Store in corrosive resistant/… container with a resistant inner liner.
P501 Dispose of contents/container to..…

Description

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 (hydrochloride) is an ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 with an IC50 value greater than 50 μM in vitro. Acting as a prodrug, GSK-J4 is rapidly hydrolyzed in cells to the otherwise cell impermeable GSK-J1, which exhibits an IC50 value of 60 nM for the purified enzyme. When administered to human primary macrophages, GSK-J4 can reduce LPS-induced proinflammatory cytokine production, most notably including that of TNFα (IC50 = 9 μM).

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