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ChemicalBook >> CAS DataBase List >> GW 848687X

GW 848687X

GW 848687X price.
  • $89 - $994.9
  • Product name: GW 848687X
  • CAS: 612831-24-0
  • MF: C24H18ClF2NO3
  • MW: 441.85
  • EINECS:
  • MDL Number:MFCD18427968
  • Synonyms:GW 848687X;PFODPHDNBFSMOX-UHFFFAOYSA-N;2-Pyridinecarboxylic acid, 6-[2-[5-chloro-2-[(2,4-difluorophenyl)methoxy]phenyl]-1-cyclopenten-1-yl]-
6 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
Package
  • 500μg
  • 1mg
  • 5mg
  • ManufacturerAK Scientific
  • Product number6220CR
  • Product description6-[2-[5-Chloro-2-[(2,4-difluorophenyl)methoxy]phenyl]-1-cyclopentenyl]pyridine-2-carboxylicAcid
  • Packaging1mg
  • Price$284
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number6220CR
  • Product description6-[2-[5-Chloro-2-[(2,4-difluorophenyl)methoxy]phenyl]-1-cyclopentenyl]pyridine-2-carboxylicAcid
  • Packaging5mg
  • Price$877
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028425
  • Product description6-(2-(5-CHLORO-2-((2,4-DIFLUOROPHENYL)METHOXY)PHENYL)-1-CYCLOPENTEN-1-YL)-2-PYRIDINECARBOXYLIC ACID 95.00%
  • Packaging5MG
  • Price$994.9
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010410
  • Product descriptionGW 848687X ≥98%
  • Packaging500μg
  • Price$89
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010410
  • Product descriptionGW 848687X ≥98%
  • Packaging1mg
  • Price$168
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010410
  • Product descriptionGW 848687X ≥98%
  • Packaging5mg
  • Price$700
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6220CR 6-[2-[5-Chloro-2-[(2,4-difluorophenyl)methoxy]phenyl]-1-cyclopentenyl]pyridine-2-carboxylicAcid 1mg $284 2021-12-16 Buy
AK Scientific 6220CR 6-[2-[5-Chloro-2-[(2,4-difluorophenyl)methoxy]phenyl]-1-cyclopentenyl]pyridine-2-carboxylicAcid 5mg $877 2021-12-16 Buy
American Custom Chemicals Corporation API0028425 6-(2-(5-CHLORO-2-((2,4-DIFLUOROPHENYL)METHOXY)PHENYL)-1-CYCLOPENTEN-1-YL)-2-PYRIDINECARBOXYLIC ACID 95.00% 5MG $994.9 2021-12-16 Buy
Cayman Chemical 10010410 GW 848687X ≥98% 500μg $89 2024-03-01 Buy
Cayman Chemical 10010410 GW 848687X ≥98% 1mg $168 2024-03-01 Buy
Cayman Chemical 10010410 GW 848687X ≥98% 5mg $700 2024-03-01 Buy

Properties

Boiling point :622.8±55.0 °C(Predicted)
Density :1.393±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
pka :1.09±0.50(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Four G protein-coupled receptors, EP1-4, initiate cellular signaling in response to prostaglandin PGE2. The receptor EP1 acts via Gαq to evoke diverse effects, including renal vasoconstriction, bronchoconstriction, hyperalgesia, allodynia, gastric protection, hyperthermia, and sleep inhibition. GW 848687X is a potent and selective EP1 receptor antagonist (IC50 = 2. nM). It has >400-fold selectivity for EP1 relative to the other EP receptor subtypes, the PGD2 receptor, DP1, and the prostacyclin receptor, IP. GW 848687X has 30-fold selectivity over the thromboxane A2 receptor, TP, acting as a functional antagonist at this receptor at higher levels. Its actions against the FP and CRTH2/DP2 receptors have not been characterized. In vivo, GW 848687X has an excellent oral pharmacokinetic profile, with oral bioavailability at 54% in rats and 53% in dogs with a half-life of two hours in both species. In a rat model of chronic inflammatory joint pain, GW 848687X shows complete anti-hyperalgesic activity.