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ChemicalBook >> CAS DataBase List >> HAMI3379

HAMI3379

HAMI3379 price.
  • $48 - $2150
  • Product name: HAMI3379
  • CAS: 712313-35-4
  • MF: C34H45NO8
  • MW: 595.72
  • EINECS:
  • MDL Number:MFCD19441770
  • Synonyms:HAMI3379;HRJWSEPIRZRGCL-UHFFFAOYSA-N;(Rac)-HAMI 3379;(Rac) HAMI 3379,(Rac)HAMI 3379;N-(3-carboxy-cyclo-hexyl-)-5-carboxy-2-(cyclo-hexyl-oxy-butyl-oxy-phenyl-propyl-oxy-)-benz-amide;Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-[4-(cyclohexyloxy)butoxy]phenyl]propoxy]-
9 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerAK Scientific
  • Product number7522CR
  • Product description3-[(3-Carboxycyclohexyl)carbamoyl]-4-[3-[4-(4-cyclohexyloxybutoxy)phenyl]propoxy]benzoicAcid
  • Packaging1mg
  • Price$158
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3082
  • Product descriptionHAMI3379
  • Packaging5mg
  • Price$269
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10580
  • Product descriptionHAMI3379 ≥90%
  • Packaging1mg
  • Price$48
  • Updated2023-01-06
  • Buy
  • ManufacturerCayman Chemical
  • Product number10580
  • Product descriptionHAMI3379 ≥90%
  • Packaging5mg
  • Price$210
  • Updated2023-01-06
  • Buy
  • ManufacturerCayman Chemical
  • Product number10580
  • Product descriptionHAMI3379 ≥90%
  • Packaging10mg
  • Price$373
  • Updated2023-01-06
  • Buy
  • ManufacturerCayman Chemical
  • Product number10580
  • Product descriptionHAMI3379 ≥90%
  • Packaging25mg
  • Price$814
  • Updated2023-01-06
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0044263
  • Product descriptionHAMI3379
  • Packaging5mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0044263
  • Product descriptionHAMI3379
  • Packaging10mg
  • Price$1050
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0044263
  • Product descriptionHAMI3379
  • Packaging25mg
  • Price$2150
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 7522CR 3-[(3-Carboxycyclohexyl)carbamoyl]-4-[3-[4-(4-cyclohexyloxybutoxy)phenyl]propoxy]benzoicAcid 1mg $158 2021-12-16 Buy
ApexBio Technology C3082 HAMI3379 5mg $269 2021-12-16 Buy
Cayman Chemical 10580 HAMI3379 ≥90% 1mg $48 2023-01-06 Buy
Cayman Chemical 10580 HAMI3379 ≥90% 5mg $210 2023-01-06 Buy
Cayman Chemical 10580 HAMI3379 ≥90% 10mg $373 2023-01-06 Buy
Cayman Chemical 10580 HAMI3379 ≥90% 25mg $814 2023-01-06 Buy
ChemScene CS-0044263 HAMI3379 5mg $750 2021-12-16 Buy
ChemScene CS-0044263 HAMI3379 10mg $1050 2021-12-16 Buy
ChemScene CS-0044263 HAMI3379 25mg $2150 2021-12-16 Buy

Properties

Boiling point :797.7±60.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤5mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :crystalline solid
pka :4.20±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The cysteinyl leukotrienes (CysLTs) LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G protein-coupled receptors, CysLT1 and CysLT2. HAMI3379 is a potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 37.9 and >30,000 nM, respectively. In a CysLT2 receptor reporter cell line, HAMI3379 antagonizes LTD4- and LTC4-induced intracellular calcium mobilization with IC50 values of 3.8 and 4.4 nM, respectively, whereas it only weakly inhibits that for a CysLT1 receptor reporter cell line (IC50 = >10,000 nM). In isolated Langendorff-perfused guinea pig hearts, HAMI3379 reverses the LTC4-stimulated increase in perfusion pressure and decrease in contractility.