Hygrolidin
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- $319 - $1659
- Product name: Hygrolidin
- CAS: 83329-73-1
- MF: C38H58O11
- MW: 690.86
- EINECS:
- MDL Number:MFCD16876182
- Synonyms:1166C;Antibiotic 1166C;Hygrolidin;2-Butenedioic acid (2E)-, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester (9CI)
5 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- TRC
Package
- 1mg
- 5mg
- ManufacturerAK Scientific
- Product number4622ED
- Product description(E)-4-[6-Ethyl-2-hydroxy-2-[3-hydroxy-4-[(4Z,6Z,12Z,14Z)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy-4-oxobut-2-enoicacid
- Packaging1mg
- Price$545
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4622ED
- Product description(E)-4-[6-Ethyl-2-hydroxy-2-[3-hydroxy-4-[(4Z,6Z,12Z,14Z)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy-4-oxobut-2-enoicacid
- Packaging5mg
- Price$1659
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28116
- Product descriptionHygrolidin
- Packaging1mg
- Price$319
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28116
- Product descriptionHygrolidin
- Packaging5mg
- Price$1276
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberH997603
- Product descriptionHygrolidin
- Packaging1mg
- Price$375
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4622ED | (E)-4-[6-Ethyl-2-hydroxy-2-[3-hydroxy-4-[(4Z,6Z,12Z,14Z)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy-4-oxobut-2-enoicacid | 1mg | $545 | 2021-12-16 | Buy |
| AK Scientific | 4622ED | (E)-4-[6-Ethyl-2-hydroxy-2-[3-hydroxy-4-[(4Z,6Z,12Z,14Z)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy-4-oxobut-2-enoicacid | 5mg | $1659 | 2021-12-16 | Buy |
| Cayman Chemical | 28116 | Hygrolidin | 1mg | $319 | 2024-03-01 | Buy |
| Cayman Chemical | 28116 | Hygrolidin | 5mg | $1276 | 2024-03-01 | Buy |
| TRC | H997603 | Hygrolidin | 1mg | $375 | 2021-12-16 | Buy |
Properties
Boiling point :821.1±65.0 °C(Predicted)
Density :1.17±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :A solid
pka :3.28±0.10(Predicted)
Density :1.17±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :A solid
pka :3.28±0.10(Predicted)
Safety Information
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Description
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively).Suppliers and manufacturers
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