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ChemicalBook >> CAS DataBase List >> INCB 3284 diMesylate

INCB 3284 diMesylate

INCB 3284 diMesylate price.
  • $36 - $1538.99
  • Product name: INCB 3284 diMesylate
  • CAS: 887401-93-6
  • MF: C26H31F3N4O4
  • MW: 520.5439496
  • EINECS:
  • MDL Number:MFCD20926352
  • Synonyms:INCB 3284 diMesylate;INCB3284;INCB 3284 biMesylate;INCB 3284 dimesylate, >=98%;N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide,methanesulfonic acid;N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide;CS-352;N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate
13 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 5mg
  • 1mg
  • 50
  • 10mg
  • 50MG
  • ManufacturerAK Scientific
  • Product numberX5402
  • Product descriptionN-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamidedimethanesulfonate
  • Packaging10mg
  • Price$226
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010326
  • Product descriptionN-[2-[[(3R)-1-[TRANS-4-HYDROXY-4-(6-METHOXY-3-PYRIDINYL)CYCLOHEXYL]-3-PYRROLIDINYL]AMINO]-2-OXOETHYL]-3-(TRIFLUOROMETHYL)BENZAMIDE DIMETHANESULFONATE 95.00%
  • Packaging10MG
  • Price$818.61
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010326
  • Product descriptionN-[2-[[(3R)-1-[TRANS-4-HYDROXY-4-(6-METHOXY-3-PYRIDINYL)CYCLOHEXYL]-3-PYRROLIDINYL]AMINO]-2-OXOETHYL]-3-(TRIFLUOROMETHYL)BENZAMIDE DIMETHANESULFONATE 95.00%
  • Packaging50MG
  • Price$1538.99
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3492
  • Product descriptionINCB3284dimesylate
  • Packaging10mg
  • Price$242
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3492
  • Product descriptionINCB3284dimesylate
  • Packaging50mg
  • Price$845
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11963
  • Product descriptionINCB 3284 (dimesylate) ≥95%
  • Packaging1mg
  • Price$36
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11963
  • Product descriptionINCB 3284 (dimesylate) ≥95%
  • Packaging5mg
  • Price$94
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11963
  • Product descriptionINCB 3284 (dimesylate) ≥95%
  • Packaging10mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11963
  • Product descriptionINCB 3284 (dimesylate) ≥95%
  • Packaging50mg
  • Price$535
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number4306
  • Product descriptionINCB3284dimesylate ≥98%(HPLC)
  • Packaging10
  • Price$263
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4306
  • Product descriptionINCB3284dimesylate ≥98%(HPLC)
  • Packaging50
  • Price$1078
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD461080
  • Product descriptionINCB3284Dimesylate
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number255506
  • Product descriptionINCB 3284 dimesylate
  • Packaging10mg
  • Price$516
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X5402 N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamidedimethanesulfonate 10mg $226 2021-12-16 Buy
American Custom Chemicals Corporation API0010326 N-[2-[[(3R)-1-[TRANS-4-HYDROXY-4-(6-METHOXY-3-PYRIDINYL)CYCLOHEXYL]-3-PYRROLIDINYL]AMINO]-2-OXOETHYL]-3-(TRIFLUOROMETHYL)BENZAMIDE DIMETHANESULFONATE 95.00% 10MG $818.61 2021-12-16 Buy
American Custom Chemicals Corporation API0010326 N-[2-[[(3R)-1-[TRANS-4-HYDROXY-4-(6-METHOXY-3-PYRIDINYL)CYCLOHEXYL]-3-PYRROLIDINYL]AMINO]-2-OXOETHYL]-3-(TRIFLUOROMETHYL)BENZAMIDE DIMETHANESULFONATE 95.00% 50MG $1538.99 2021-12-16 Buy
ApexBio Technology A3492 INCB3284dimesylate 10mg $242 2021-12-16 Buy
ApexBio Technology A3492 INCB3284dimesylate 50mg $845 2021-12-16 Buy
Cayman Chemical 11963 INCB 3284 (dimesylate) ≥95% 1mg $36 2024-03-01 Buy
Cayman Chemical 11963 INCB 3284 (dimesylate) ≥95% 5mg $94 2024-03-01 Buy
Cayman Chemical 11963 INCB 3284 (dimesylate) ≥95% 10mg $116 2024-03-01 Buy
Cayman Chemical 11963 INCB 3284 (dimesylate) ≥95% 50mg $535 2024-03-01 Buy
Tocris 4306 INCB3284dimesylate ≥98%(HPLC) 10 $263 2021-12-16 Buy
Tocris 4306 INCB3284dimesylate ≥98%(HPLC) 50 $1078 2021-12-16 Buy
TRC D461080 INCB3284Dimesylate 10mg $90 2021-12-16 Buy
Usbiological 255506 INCB 3284 dimesylate 10mg $516 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF:11.0(Max Conc. mg/mL);15.43(Max Conc. mM)
DMSO:57.19(Max Conc. mg/mL);80.24(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);7.02(Max Conc. mM)
Water:71.28(Max Conc. mg/mL);100.0(Max Conc. mM) form :Powder
color :Colorless to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CCR2 is the receptor for the chemokine CCL2, known commonly as monocyte chemotactic protein-1 (MCP-1). INCB 3284 is a potent, selective, and orally bioavailable antagonist of monocyte chemotactic protein-1 binding to CCR2 (IC50 = 3.7 nM). For comparison, it has no significant inhibitor action at over 50 ion channels, transporters, GPCRs, and other chemokine receptors when tested at a concentration of 1 μM. INCB 3284 inhibits chemotaxis in vitro (IC50 = 4.7 nM) and displays acceptable oral bioavailability in mice, rats, dogs, monkeys, and chimpanzees.