IOX4
|
- $41 - $1443
- Product name: IOX4
- CAS: 1154097-71-8
- MF: C15H16N6O3
- MW: 328.33
- EINECS:
- MDL Number:MFCD31691406
- Synonyms:IOX4;tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;3-Pyridinecarboxylic acid, 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester;t-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;IOX4; IOX-4; IOX 4;PHD2 inhibitor IOX4;IOX4 NEW;IOX 4,HIF-PH,HIFs,Hypoxia-inducible factors,IOX4,IOX-4,inhibit,HIF/HIF Prolyl-Hydroxylase,Inhibitor
20 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- TRC
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number1602DC
- Product descriptionTert-butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate
- Packaging5mg
- Price$179
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1168587
- Product descriptiontert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98%
- Packaging5mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1168587
- Product descriptiontert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98%
- Packaging10mg
- Price$78
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1168587
- Product descriptiontert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98%
- Packaging25mg
- Price$157
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1168587
- Product descriptiontert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98%
- Packaging100mg
- Price$625
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1168587
- Product descriptiontert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98%
- Packaging250mg
- Price$1443
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4672
- Product descriptionIOX4
- Packaging5mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4672
- Product descriptionIOX4
- Packaging10mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4672
- Product descriptionIOX4
- Packaging25mg
- Price$369
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4672
- Product descriptionIOX4
- Packaging50mg
- Price$654
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18181
- Product descriptionIOX4 ≥98%
- Packaging5mg
- Price$73
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18181
- Product descriptionIOX4 ≥98%
- Packaging10mg
- Price$138
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18181
- Product descriptionIOX4 ≥98%
- Packaging25mg
- Price$324
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18181
- Product descriptionIOX4 ≥98%
- Packaging50mg
- Price$575
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0069508
- Product descriptionIOX4 99.78%
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0069508
- Product descriptionIOX4 99.78%
- Packaging10mg
- Price$105
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1602DC | Tert-butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate | 5mg | $179 | 2021-12-16 | Buy |
| Ambeed | A1168587 | tert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98% | 5mg | $41 | 2021-12-16 | Buy |
| Ambeed | A1168587 | tert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98% | 10mg | $78 | 2021-12-16 | Buy |
| Ambeed | A1168587 | tert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98% | 25mg | $157 | 2021-12-16 | Buy |
| Ambeed | A1168587 | tert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98% | 100mg | $625 | 2021-12-16 | Buy |
| Ambeed | A1168587 | tert-Butyl6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate 98% | 250mg | $1443 | 2021-12-16 | Buy |
| ApexBio Technology | C4672 | IOX4 | 5mg | $82 | 2021-12-16 | Buy |
| ApexBio Technology | C4672 | IOX4 | 10mg | $154 | 2021-12-16 | Buy |
| ApexBio Technology | C4672 | IOX4 | 25mg | $369 | 2021-12-16 | Buy |
| ApexBio Technology | C4672 | IOX4 | 50mg | $654 | 2021-12-16 | Buy |
| Cayman Chemical | 18181 | IOX4 ≥98% | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 18181 | IOX4 ≥98% | 10mg | $138 | 2024-03-01 | Buy |
| Cayman Chemical | 18181 | IOX4 ≥98% | 25mg | $324 | 2024-03-01 | Buy |
| Cayman Chemical | 18181 | IOX4 ≥98% | 50mg | $575 | 2024-03-01 | Buy |
| ChemScene | CS-0069508 | IOX4 99.78% | 5mg | $55 | 2021-12-16 | Buy |
| ChemScene | CS-0069508 | IOX4 99.78% | 10mg | $105 | 2021-12-16 | Buy |
Properties
Melting point :>190° (dec.)
Boiling point :502.2±60.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Refrigerator, Under inert atmosphere
solubility :DMSO (Sparingly, Sonicated), Methanol (Slightly, Sonicated)
form :Solid
pka :1.36±0.29(Predicted)
color :Light Beige to Beige
Boiling point :502.2±60.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Refrigerator, Under inert atmosphere
solubility :DMSO (Sparingly, Sonicated), Methanol (Slightly, Sonicated)
form :Solid
pka :1.36±0.29(Predicted)
color :Light Beige to Beige
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Hypoxia-inducible factors (HIFs) are regulated by the hydroxylation of prolyl residues in oxygen-dependent degradation domains, which leads to degradation by the proteasome. HIF prolyl hydroxylation is catalyzed by prolyl hydroxylase domain enzymes (PHD1, 2, and 3), members of the Fe(II) and 2-oxoglutarate (2OG) oxygenase family. They require dioxygen as a co-substrate, thus acting as the hypoxia-sensing component of the HIF system. IOX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM). It displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and increasing HIF-1α levels in cells (IC50 values range from 5.6 to 11.7 μM) and inducing HIF-1α and HIF-2α expression in mice. The induction of HIF expression in mice occurs in the brain as well as in the liver, kidney, and heart, indicating that IOX4 penetrates the blood-brain barrier.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
InvivoChem
LEAP CHEM CO., LTD.
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
HangZhou YuHao Chemical Technology Co., Ltd.
Shanghai Lollane Biological Technology Co.,Ltd.