IRF3 Polyclonal Antibody
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- $364
- Product name: IRF3 Polyclonal Antibody
- CAS:
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- MW: 0
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- Synonyms:IRF3 Polyclonal Antibody
1 prices
Selected condition:
Brand
- Cayman Chemical
Package
- 100μg
- ManufacturerCayman Chemical
- Product number24937
- Product descriptionIRF3 Polyclonal Antibody
- Packaging100μg
- Price$364
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Cayman Chemical | 24937 | IRF3 Polyclonal Antibody | 100μg | $364 | 2024-03-01 | Buy |
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Description
Interferon regulatory factor 3 (IRF3) is a member of the IRF family that plays a crucial role in activation of innate immunity and inflammation in response to viral infection, functioning as a molecular switch for antiviral activity. Double-stranded RNA generated during a viral infection leads to IRF3 activation through serine/threonine phosphorylation by TBK1 or IKKε (IKBKE) kinases, which induces a conformational change leading to its dimerization, nuclear localization, and association with CREB binding protein (CREBBP)/p300. The complex formed by this association, known as DRAF1, activates transcription of interferon α (IFN-α) and IFN-β as well as other IFN-induced genes, which play a critical role in the type 1 IFN-dependent immune response. Cayman’s IRF3 Polyclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes IRF3 at ~47 kDa from human samples.Suppliers and manufacturers
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