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ChemicalBook >> CAS DataBase List >> ISRIB (trans-isoMer)

ISRIB (trans-isoMer)

ISRIB (trans-isoMer) price.
  • $81 - $1600
  • Product name: ISRIB (trans-isoMer)
  • CAS: 1597403-47-8
  • MF: C22H24Cl2N2O4
  • MW: 451.34
  • EINECS:
  • MDL Number:MFCD27952932
  • Synonyms:ISRIB (trans-isoMer);trans-N,N'-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide);N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) ISRIB(trans-isomer);Trans-ISRIB;Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-;N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide];CS-1768;ISRIB - trans-ISRIB
19 prices
Selected condition:
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • Usbiological
Package
  • 10
  • 5MG
  • 10mg
  • 25mg
  • 50
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0027387
  • Product descriptionTRANS-N,N'-(CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE) 95.00%
  • Packaging5MG
  • Price$504.28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3699
  • Product descriptionISRIB(trans-isomer)
  • Packaging10mg
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2278
  • Product descriptionISRIB-trans-ISRIB 99%
  • Packaging10mg
  • Price$104.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2278
  • Product descriptionISRIB-trans-ISRIB 99%
  • Packaging50mg
  • Price$374
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16258
  • Product descriptiontrans-ISRIB ≥95%
  • Packaging5mg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16258
  • Product descriptiontrans-ISRIB ≥95%
  • Packaging10mg
  • Price$152
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16258
  • Product descriptiontrans-ISRIB ≥95%
  • Packaging25mg
  • Price$356
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3602
  • Product descriptionISRIBtrans-isomer 99.37%
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3602
  • Product descriptionISRIBtrans-isomer 99.37%
  • Packaging50mg
  • Price$432
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3602
  • Product descriptionISRIBtrans-isomer 99.37%
  • Packaging100mg
  • Price$780
  • Updated2021-12-16
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  • ManufacturerDC Chemicals
  • Product numberDC7431
  • Product descriptionISRIB >98%
  • Packaging100mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7431
  • Product descriptionISRIB >98%
  • Packaging250mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7431
  • Product descriptionISRIB >98%
  • Packaging1g
  • Price$1600
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number46960
  • Product descriptionISRIB
  • Packaging25mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0843
  • Product descriptionISRIB ≥98%(HPLC)
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0843
  • Product descriptionISRIB ≥98% (HPLC)
  • Packaging25MG
  • Price$478
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation API0027387 TRANS-N,N'-(CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE) 95.00% 5MG $504.28 2021-12-16 Buy
ApexBio Technology B3699 ISRIB(trans-isomer) 10mg $109 2021-12-16 Buy
Axon Medchem Axon2278 ISRIB-trans-ISRIB 99% 10mg $104.5 2021-12-16 Buy
Axon Medchem Axon2278 ISRIB-trans-ISRIB 99% 50mg $374 2021-12-16 Buy
Cayman Chemical 16258 trans-ISRIB ≥95% 5mg $81 2024-03-01 Buy
Cayman Chemical 16258 trans-ISRIB ≥95% 10mg $152 2024-03-01 Buy
Cayman Chemical 16258 trans-ISRIB ≥95% 25mg $356 2024-03-01 Buy
ChemScene CS-3602 ISRIBtrans-isomer 99.37% 10mg $130 2021-12-16 Buy
ChemScene CS-3602 ISRIBtrans-isomer 99.37% 50mg $432 2021-12-16 Buy
ChemScene CS-3602 ISRIBtrans-isomer 99.37% 100mg $780 2021-12-16 Buy
DC Chemicals DC7431 ISRIB >98% 100mg $400 2021-12-16 Buy
DC Chemicals DC7431 ISRIB >98% 250mg $800 2021-12-16 Buy
DC Chemicals DC7431 ISRIB >98% 1g $1600 2021-12-16 Buy
Medical Isotopes, Inc. 46960 ISRIB 25mg $800 2021-12-16 Buy
Sigma-Aldrich SML0843 ISRIB ≥98%(HPLC) 5mg $118 2024-03-01 Buy
Sigma-Aldrich SML0843 ISRIB ≥98% (HPLC) 25MG $478 2024-03-01 Buy

Properties

Boiling point :719.0±60.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in EtOH; insoluble in H2O; insoluble in EtOH; ≥8.96 mg/mL in DMSO with gentle warming
form :solid
pka :13.63±0.40(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
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Description

Phosphorylation of eIF2α by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay). Although the mechanism of action is not established, it does not directly inhibit phosphorylation of eIF2α by upstream kinases. trans-ISRIB is able to pass through the blood-brain barrier and significantly enhances learning and memory in mice and rats.

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