ITF2357
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- $45 - $834
- Product name: ITF2357
- CAS: 732302-99-7
- MF: C24H30ClN3O5
- MW: 475.9651
- EINECS:200-258-5
- MDL Number:MFCD18385007
- Synonyms:(6-((diethylamino)methyl)naphthalen-2-yl)methyl 4-(hydroxycarbamoyl)phenylcarbamate hydrochloride hydrate;ITF2357;ITF2357 (Givinostat);N-[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester hydrochloride hydrate;Givinostat (hydrochloride monohydrate);Givinostat Hydrochloride Hydrate;Givinostat (ITF2357) HCl monohydrate;Givinostat(HCl hydrate)
16 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- Sigma-Aldrich
- TRC
Package
- 1MG
- 5MG
- 10mg
- 25MG
- 50mg
- ManufacturerAK Scientific
- Product numberX7528
- Product descriptionGivinostat
- Packaging50mg
- Price$834
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007793
- Product descriptionITF2357 95.00%
- Packaging1MG
- Price$153.3
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007793
- Product descriptionITF2357 95.00%
- Packaging5MG
- Price$495.94
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4093
- Product descriptionITF2357(Givinostat)
- Packaging50mg
- Price$670
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60369
- Product descriptionGivinostat(ITF2357)
- Packaging5mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11045
- Product descriptionITF 2357 ≥98%
- Packaging1mg
- Price$45
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11045
- Product descriptionITF 2357 ≥98%
- Packaging5mg
- Price$121
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11045
- Product descriptionITF 2357 ≥98%
- Packaging10mg
- Price$220
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-7576
- Product descriptionGivinostathydrochloridemonohydrate ≥98.0%
- Packaging5mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7576
- Product descriptionGivinostathydrochloridemonohydrate ≥98.0%
- Packaging10mg
- Price$228
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7576
- Product descriptionGivinostathydrochloridemonohydrate ≥98.0%
- Packaging50mg
- Price$804
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD12038665
- Product descriptionGivinostatHydrochlorideHydrate 95+%
- Packaging50mg
- Price$570
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD12038665
- Product descriptionGivinostatHydrochlorideHydrate 95+%
- Packaging10mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1772
- Product descriptionGivinostat hydrochloride hydrate ≥95% (HPLC)
- Packaging25MG
- Price$542
- Updated2023-06-20
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1772
- Product descriptionGivinostat hydrochloride hydrate ≥95% (HPLC)
- Packaging5MG
- Price$135
- Updated2023-06-20
- Buy
- ManufacturerTRC
- Product numberG388775
- Product descriptionGivinostatHydrochlorideHydrate
- Packaging25mg
- Price$440
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7528 | Givinostat | 50mg | $834 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007793 | ITF2357 95.00% | 1MG | $153.3 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007793 | ITF2357 95.00% | 5MG | $495.94 | 2021-12-16 | Buy |
| ApexBio Technology | A4093 | ITF2357(Givinostat) | 50mg | $670 | 2021-12-16 | Buy |
| Arctom | CFN60369 | Givinostat(ITF2357) | 5mg | $208 | 2021-12-16 | Buy |
| Cayman Chemical | 11045 | ITF 2357 ≥98% | 1mg | $45 | 2024-03-01 | Buy |
| Cayman Chemical | 11045 | ITF 2357 ≥98% | 5mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 11045 | ITF 2357 ≥98% | 10mg | $220 | 2024-03-01 | Buy |
| ChemScene | CS-7576 | Givinostathydrochloridemonohydrate ≥98.0% | 5mg | $132 | 2021-12-16 | Buy |
| ChemScene | CS-7576 | Givinostathydrochloridemonohydrate ≥98.0% | 10mg | $228 | 2021-12-16 | Buy |
| ChemScene | CS-7576 | Givinostathydrochloridemonohydrate ≥98.0% | 50mg | $804 | 2021-12-16 | Buy |
| Crysdot | CD12038665 | GivinostatHydrochlorideHydrate 95+% | 50mg | $570 | 2021-12-16 | Buy |
| Crysdot | CD12038665 | GivinostatHydrochlorideHydrate 95+% | 10mg | $200 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML1772 | Givinostat hydrochloride hydrate ≥95% (HPLC) | 25MG | $542 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1772 | Givinostat hydrochloride hydrate ≥95% (HPLC) | 5MG | $135 | 2023-06-20 | Buy |
| TRC | G388775 | GivinostatHydrochlorideHydrate | 25mg | $440 | 2021-12-16 | Buy |
Properties
storage temp. :-20°C
solubility :≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
form :powder
color :white to beige
CAS DataBase Reference :732302-99-7
solubility :≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
form :powder
color :white to beige
CAS DataBase Reference :732302-99-7
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
ITF 2357 inhibits class I and class II histone deacetylases (maize HDACs: HD2, HD-1B, and HD-1A with IC50s = 7.5-16 nM) and reduces the production of several pro-inflammatory cytokines including TNFα, IL-1α, and IL-1β (IC50s = 10-22 nM). ITF 2357 also has activity against cells expressing janus kinase 2 (JAK2)V617F (IC50s = 1-10 nM), a mutated form of the JAK2 enzyme that is implicated in the pathophysiology of many myeloproliferative diseases, including polycythaemia vera.Related product price
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