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ChemicalBook >> CAS DataBase List >> IWP-3

IWP-3

IWP-3 price.
  • $38 - $1000
  • Product name: IWP-3
  • CAS: 687561-60-0
  • MF: C22H17FN4O2S3
  • MW: 484.59
  • EINECS:200-258-5
  • MDL Number:MFCD04457889
  • Synonyms:IWP-3;2-[[3-(4-Fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-acetamide;Wnt Inhibitor IWP-3;2-((3-(4-fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide;IWP 3;IWP3;Acetamide, 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-;IWP-3 >=98% (HPLC)
Price17 Properties Safety Information Description
17 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • ApexBio Technology
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number6566CG
  • Product description2-[[3-(4-Fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
  • Packaging1mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number687561600
  • Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
  • Packaging10mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number687561600
  • Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
  • Packaging25mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3254
  • Product descriptionIWP-3
  • Packaging5mg
  • Price$137
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3254
  • Product descriptionIWP-3
  • Packaging10mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3254
  • Product descriptionIWP-3
  • Packaging25mg
  • Price$541
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13953
  • Product descriptionIWP-3 ≥98%
  • Packaging1mg
  • Price$38
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13953
  • Product descriptionIWP-3 ≥98%
  • Packaging5mg
  • Price$120
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13953
  • Product descriptionIWP-3 ≥98%
  • Packaging10mg
  • Price$220
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13953
  • Product descriptionIWP-3 ≥98%
  • Packaging25mg
  • Price$475
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00002608
  • Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 97%
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00002608
  • Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 97%
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00002608
  • Product description2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 97%
  • Packaging25mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC5059
  • Product descriptionIWP-3 >98%
  • Packaging250mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0533
  • Product descriptionIWP-3 ≥98% (HPLC)
  • Packaging5mg
  • Price$149
  • Updated2022-05-15
  • Buy
  • ManufacturerTRC
  • Product numberI941620
  • Product descriptionIWP-3
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6566CG 2-[[3-(4-Fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide 1mg $140 2021-12-16 Buy
Alichem 687561600 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 10mg $168 2021-12-16 Buy
Alichem 687561600 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 25mg $350 2021-12-16 Buy
ApexBio Technology C3254 IWP-3 5mg $137 2021-12-16 Buy
ApexBio Technology C3254 IWP-3 10mg $250 2021-12-16 Buy
ApexBio Technology C3254 IWP-3 25mg $541 2021-12-16 Buy
Cayman Chemical 13953 IWP-3 ≥98% 1mg $38 2024-03-01 Buy
Cayman Chemical 13953 IWP-3 ≥98% 5mg $120 2024-03-01 Buy
Cayman Chemical 13953 IWP-3 ≥98% 10mg $220 2024-03-01 Buy
Cayman Chemical 13953 IWP-3 ≥98% 25mg $475 2024-03-01 Buy
Crysdot CD00002608 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 97% 5mg $90 2021-12-16 Buy
Crysdot CD00002608 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 97% 10mg $160 2021-12-16 Buy
Crysdot CD00002608 2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 97% 25mg $350 2021-12-16 Buy
DC Chemicals DC5059 IWP-3 >98% 250mg $1000 2021-12-16 Buy
Sigma-Aldrich SML0533 IWP-3 ≥98% (HPLC) 5mg $149 2022-05-15 Buy
TRC I941620 IWP-3 10mg $130 2021-12-16 Buy
Next Last

Properties

Melting point :>248°C (dec.)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-3 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 40 nM. IWP-3 inactivates porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-3 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 (LRP6) and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. By inhibiting Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC50 = 1.2 μM).

Suppliers and manufacturers

career henan chemical co
IWP-3
$1.00 /1g
IWP-3 CAS:687561-60-0
InvivoChem
Aladdin Scientific AdooQ BioScience, LLC AdooQ Bioscience CHINA Sigma-Aldrich Shanghai Lollane Biological Technology Co.,Ltd. Shanghai EFE Biological Technology Co., Ltd. Shanghai Changyan Chem & Tech Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd.