Inauhzin
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- $28 - $2400
- Product name: Inauhzin
- CAS: 309271-94-1
- MF: C25H19N5OS2
- MW: 469.58
- EINECS:
- MDL Number:MFCD01819836
- Synonyms:Inauhzin, >=98%;2-((5H-[1,2,4]Triazino[5,6-b]indol-3-yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one;Inauhzin;1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin);2-(9H-[1,2,4]TRIAZINO[6,5-B]INDOL-3-YLTHIO)-1-(10H-PHENOTHIAZIN-10-YL)BUTAN-1-ONE;10-[1-Oxo-2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)butyl]-10H-phenothiazine;Inauhzin(INZ);10-[1-Oxo-2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)butyl]-10H-phenothiazine Inauhzin(INZ)
24 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 1unit
- 5MG
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- 1000mg
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004468
- Product description1-PHENOTHIAZIN-10-YL-2-(9H-1,3,4,9-TETRAAZA-FLUOREN-2-YLSUFANYL)-BUTAN-1-ONE 95.00%
- Packaging5MG
- Price$502
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3272
- Product descriptionInauhzin
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3272
- Product descriptionInauhzin
- Packaging10mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3272
- Product descriptionInauhzin
- Packaging10mM(in 1mL DMSO)
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3272
- Product descriptionInauhzin
- Packaging50mg
- Price$299
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181257
- Product descriptionInauhzin >98%
- Packaging100mg
- Price$578
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181257
- Product descriptionInauhzin >98%
- Packaging250mg
- Price$1133.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181257
- Product descriptionInauhzin >98%
- Packaging1000mg
- Price$2245.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19771
- Product descriptionInauhzin ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19771
- Product descriptionInauhzin ≥98%
- Packaging5mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19771
- Product descriptionInauhzin ≥98%
- Packaging10mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-2404
- Product descriptionInauhzin 99.49%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2404
- Product descriptionInauhzin 99.49%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2404
- Product descriptionInauhzin 99.49%
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2404
- Product descriptionInauhzin 99.49%
- Packaging100mg
- Price$780
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002308
- Product descriptionInauhzin 98+%
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | INB0004468 | 1-PHENOTHIAZIN-10-YL-2-(9H-1,3,4,9-TETRAAZA-FLUOREN-2-YLSUFANYL)-BUTAN-1-ONE 95.00% | 5MG | $502 | 2021-12-16 | Buy |
| ApexBio Technology | B3272 | Inauhzin | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | B3272 | Inauhzin | 10mg | $99 | 2021-12-16 | Buy |
| ApexBio Technology | B3272 | Inauhzin | 10mM(in 1mL DMSO) | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B3272 | Inauhzin | 50mg | $299 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181257 | Inauhzin >98% | 100mg | $578 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181257 | Inauhzin >98% | 250mg | $1133.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181257 | Inauhzin >98% | 1000mg | $2245.7 | 2021-12-16 | Buy |
| Cayman Chemical | 19771 | Inauhzin ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19771 | Inauhzin ≥98% | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 19771 | Inauhzin ≥98% | 10mg | $184 | 2024-03-01 | Buy |
| ChemScene | CS-2404 | Inauhzin 99.49% | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-2404 | Inauhzin 99.49% | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-2404 | Inauhzin 99.49% | 50mg | $540 | 2021-12-16 | Buy |
| ChemScene | CS-2404 | Inauhzin 99.49% | 100mg | $780 | 2021-12-16 | Buy |
| Crysdot | CD31002308 | Inauhzin 98+% | 5mg | $70 | 2021-12-16 | Buy |
Properties
Boiling point :773.6±70.0 °C(Predicted)
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :10.24±0.50(Predicted)
color :Light yellow to yellow
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :10.24±0.50(Predicted)
color :Light yellow to yellow
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Inauhzin is a cell-permeable, SIRT1 inhibitor (IC50 = 0.7-2 μM) that reactivates p53 by inhibiting SIRT1 deacetylation activity. It binds directly to SIRT1 and does not affect SIRT2, SIRT3, or HDAC8. Inauhzin has been shown to inhibit cell proliferation by inducing p53-dependent apoptosis in various human cancer cells (IC50s = 5.4, 51.9, 3.2, 33.9, and 85.4 μM for H460, H1299, A549, HT-29, and WI38 cells, respectively), as well as in xenograft tumors derived from H460 cells. It has also been shown to activate p53 synergistically with the Mdm2 inhibitor nutlin-3 , sensitizing cancer cells to cisplatin and doxorubicin .Suppliers and manufacturers
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