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ChemicalBook >> CAS DataBase List >> Ingenol mebutate

Ingenol mebutate

Ingenol mebutate price.
  • $74 - $2150
  • Product name: Ingenol mebutate
  • CAS: 75567-37-2
  • MF: C25H34O6
  • MW: 430.53
  • EINECS:
  • MDL Number:MFCD22683801
  • Synonyms:Ingenol-3-O-angelate;Picato;(1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-Dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a- methanocyclopenta(a)cyclopropa(e)cyclodecen-6-yl (2Z)-2-methylbut-2-enoate;Ingenol mebutate;Ingenol Mebutate, >98%;Ingenol 3-mebutate;Ingenol-3-O-angelate 75567-37-2;PEP005; INGENOL MEBUTATE; I3A
25 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • Arctom
  • AvaChem
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 500μg
  • 1mg
  • 2mg
  • 2.5mg
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 100mg
  • 250mg
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0012-M005
  • Product descriptionIngenol-3-angelate ≥97%(HPLC)
  • Packaging5mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3737AH
  • Product descriptionIngenol3-angelate
  • Packaging10mg
  • Price$977
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ60601
  • Product descriptionIngenol 3-angelate, 98%
  • Packaging1mg
  • Price$306
  • Updated2023-06-20
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005276
  • Product descriptionINGENOL 3-ANGELATE 95.00%
  • Packaging1MG
  • Price$258.3
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSY232574
  • Product descriptionIngenol-3-angelate;Ingenol?mebutate
  • Packaging10mg
  • Price$1423.64
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3018
  • Product descriptionIngenol-3-angelate
  • Packaging2mg
  • Price$89
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number3018
  • Product descriptionIngenol-3-angelate
  • Packaging5mg
  • Price$149
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number3018
  • Product descriptionIngenol-3-angelate
  • Packaging10mg
  • Price$249
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number3018
  • Product descriptionIngenol-3-angelate
  • Packaging25mg
  • Price$429
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number3018
  • Product descriptionIngenol-3-angelate
  • Packaging100mg
  • Price$1150
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number3018
  • Product descriptionIngenol-3-angelate
  • Packaging250mg
  • Price$2150
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16207
  • Product descriptionIngenol-3-angelate ≥95%
  • Packaging500μg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16207
  • Product descriptionIngenol-3-angelate ≥95%
  • Packaging1mg
  • Price$152
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16207
  • Product descriptionIngenol-3-angelate ≥95%
  • Packaging5mg
  • Price$553
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16207
  • Product descriptionIngenol-3-angelate ≥95%
  • Packaging10mg
  • Price$790
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2971
  • Product descriptionIngenolMebutate 99.07%
  • Packaging1mg
  • Price$74
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0012-M005 Ingenol-3-angelate ≥97%(HPLC) 5mg $420 2021-12-16 Buy
AK Scientific 3737AH Ingenol3-angelate 10mg $977 2021-12-16 Buy
Alfa Aesar J60601 Ingenol 3-angelate, 98% 1mg $306 2023-06-20 Buy
American Custom Chemicals Corporation API0005276 INGENOL 3-ANGELATE 95.00% 1MG $258.3 2021-12-16 Buy
Arctom SY232574 Ingenol-3-angelate;Ingenol?mebutate 10mg $1423.64 2021-12-16 Buy
AvaChem 3018 Ingenol-3-angelate 2mg $89 2021-12-16 Buy
AvaChem 3018 Ingenol-3-angelate 5mg $149 2021-12-16 Buy
AvaChem 3018 Ingenol-3-angelate 10mg $249 2021-12-16 Buy
AvaChem 3018 Ingenol-3-angelate 25mg $429 2021-12-16 Buy
AvaChem 3018 Ingenol-3-angelate 100mg $1150 2021-12-16 Buy
AvaChem 3018 Ingenol-3-angelate 250mg $2150 2021-12-16 Buy
Cayman Chemical 16207 Ingenol-3-angelate ≥95% 500μg $81 2024-03-01 Buy
Cayman Chemical 16207 Ingenol-3-angelate ≥95% 1mg $152 2024-03-01 Buy
Cayman Chemical 16207 Ingenol-3-angelate ≥95% 5mg $553 2024-03-01 Buy
Cayman Chemical 16207 Ingenol-3-angelate ≥95% 10mg $790 2024-03-01 Buy
ChemScene CS-2971 IngenolMebutate 99.07% 1mg $74 2021-12-16 Buy

Properties

Boiling point :576.9±50.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :powder
pka :11.52±0.70(Predicted)
color :white to beige
Water Solubility :Soluble in 100% ethanol, DMSO, dichloromethane, and methanol. Insoluble in water.
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger GHS hazard pictograms P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P320 Specific treatment is urgent (see … on this label).
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Ingenol-3-angelate is a hydrophobic diterpene ester that can be isolated from the euphorb E. peplus. It rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption, although it can also initiate apoptosis in some cancer cell lines (LD90 = ~190 μM). Secondarily, ingenol-3-angelate causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity. These actions have relevance in diminishing actinic keratosis and, possibly, other cancers of the skin.

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