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ChemicalBook >> CAS DataBase List >> JW 642

JW 642

JW 642 price.
  • $50 - $969
  • Product name: JW 642
  • CAS: 1416133-89-5
  • MF: C21H20F6N2O3
  • MW: 462.39
  • EINECS:
  • MDL Number:MFCD22987956
  • Synonyms:JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;JW 642; JW642;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;MAGL,inhibit,JW-642,Inhibitor,JW 642,Monoacylglycerol lipase,JW642
Price20 Properties Safety Information Description
20 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 50
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number3755AH
  • Product description1,1,1,3,3,3-Hexafluoropropan-2-yl4-(3-phenoxybenzyl)piperazine-1-carboxylate
  • Packaging5mg
  • Price$162
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3755AH
  • Product description1,1,1,3,3,3-Hexafluoropropan-2-yl4-(3-phenoxybenzyl)piperazine-1-carboxylate
  • Packaging50mg
  • Price$596
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3755AH
  • Product description1,1,1,3,3,3-Hexafluoropropan-2-yl4-(3-phenoxybenzyl)piperazine-1-carboxylate
  • Packaging100mg
  • Price$969
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5759
  • Product descriptionJW642
  • Packaging5mg
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5759
  • Product descriptionJW642
  • Packaging10mg
  • Price$268
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5759
  • Product descriptionJW642
  • Packaging50mg
  • Price$961
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11789
  • Product descriptionJW 642 ≥98%
  • Packaging5mg
  • Price$50
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11789
  • Product descriptionJW 642 ≥98%
  • Packaging10mg
  • Price$71
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11789
  • Product descriptionJW 642 ≥98%
  • Packaging50mg
  • Price$399
  • Updated2023-01-06
  • Buy
  • ManufacturerCayman Chemical
  • Product number11789
  • Product descriptionJW 642 ≥98%
  • Packaging100mg
  • Price$697
  • Updated2023-01-06
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3342
  • Product descriptionJW642 99.70%
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3342
  • Product descriptionJW642 99.70%
  • Packaging50mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3342
  • Product descriptionJW642 99.70%
  • Packaging100mg
  • Price$630
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003567
  • Product descriptionJW642 98+%
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003567
  • Product descriptionJW642 98+%
  • Packaging50mg
  • Price$224
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003567
  • Product descriptionJW642 98+%
  • Packaging100mg
  • Price$420
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3755AH 1,1,1,3,3,3-Hexafluoropropan-2-yl4-(3-phenoxybenzyl)piperazine-1-carboxylate 5mg $162 2021-12-16 Buy
AK Scientific 3755AH 1,1,1,3,3,3-Hexafluoropropan-2-yl4-(3-phenoxybenzyl)piperazine-1-carboxylate 50mg $596 2021-12-16 Buy
AK Scientific 3755AH 1,1,1,3,3,3-Hexafluoropropan-2-yl4-(3-phenoxybenzyl)piperazine-1-carboxylate 100mg $969 2021-12-16 Buy
ApexBio Technology B5759 JW642 5mg $156 2021-12-16 Buy
ApexBio Technology B5759 JW642 10mg $268 2021-12-16 Buy
ApexBio Technology B5759 JW642 50mg $961 2021-12-16 Buy
Cayman Chemical 11789 JW 642 ≥98% 5mg $50 2024-03-01 Buy
Cayman Chemical 11789 JW 642 ≥98% 10mg $71 2024-03-01 Buy
Cayman Chemical 11789 JW 642 ≥98% 50mg $399 2023-01-06 Buy
Cayman Chemical 11789 JW 642 ≥98% 100mg $697 2023-01-06 Buy
ChemScene CS-3342 JW642 99.70% 10mg $70 2021-12-16 Buy
ChemScene CS-3342 JW642 99.70% 50mg $250 2021-12-16 Buy
ChemScene CS-3342 JW642 99.70% 100mg $630 2021-12-16 Buy
Crysdot CD31003567 JW642 98+% 10mg $60 2021-12-16 Buy
Crysdot CD31003567 JW642 98+% 50mg $224 2021-12-16 Buy
Crysdot CD31003567 JW642 98+% 100mg $420 2021-12-16 Buy
Next Last

Properties

Melting point :68-70°C
Boiling point :432.9±45.0 °C(Predicted)
Density :1.354±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
form :Solid
pka :6.13±0.10(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).

Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Aladdin Scientific AdooQ BioScience, LLC Cochemical Ltd. LETOPHARM LIMITED SPIRO PHARMA Shanghai EFE Biological Technology Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd. MQ (shanghai) Pharmaceuticals Co., Ltd.