JW74
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- $32 - $1802
- Product name: JW74
- CAS: 863405-60-1
- MF: C24H20N6O2S
- MW: 456.52
- EINECS:
- MDL Number:MFCD07048962
- Synonyms:JW74;4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine;JW74;JW 74;Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-;JW74 >=98% (HPLC);Inhibitor,JW74,JW-74,JW 74,inhibit,Wnt;5-(((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-3-(p-tolyl)-1,2,4-oxadiazole
24 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 50
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2030CW
- Product description5-[[4-(4-Methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazole
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2030CW
- Product description5-[[4-(4-Methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazole
- Packaging10mg
- Price$286
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0376681
- Product description4-[4-(4-METHOXYPHENYL)-5-[[[3-(4-METHYLPHENYL)-1,2,4-OXADIAZOL-5-YL]METHYL]THIO]-4H-1,2,4-TRIAZOL-3-YL]-PYRIDINE 95.00%
- Packaging5MG
- Price$504.45
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3166
- Product descriptionJW74
- Packaging10mg
- Price$192
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611635
- Product descriptionJW-74
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611635
- Product descriptionJW-74
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611635
- Product descriptionJW-74
- Packaging1g
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19124
- Product descriptionJW 74 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19124
- Product descriptionJW 74 ≥98%
- Packaging5mg
- Price$110
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19124
- Product descriptionJW 74 ≥98%
- Packaging10mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-5463
- Product descriptionJW74 99.45%
- Packaging5mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5463
- Product descriptionJW74 99.45%
- Packaging10mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5463
- Product descriptionJW74 99.45%
- Packaging25mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5463
- Product descriptionJW74 99.45%
- Packaging50mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5463
- Product descriptionJW74 99.45%
- Packaging100mg
- Price$840
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000544
- Product descriptionJW74 98+%
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2030CW | 5-[[4-(4-Methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazole | 1mg | $133 | 2021-12-16 | Buy |
| AK Scientific | 2030CW | 5-[[4-(4-Methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazole | 10mg | $286 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0376681 | 4-[4-(4-METHOXYPHENYL)-5-[[[3-(4-METHYLPHENYL)-1,2,4-OXADIAZOL-5-YL]METHYL]THIO]-4H-1,2,4-TRIAZOL-3-YL]-PYRIDINE 95.00% | 5MG | $504.45 | 2021-12-16 | Buy |
| ApexBio Technology | C3166 | JW74 | 10mg | $192 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611635 | JW-74 | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611635 | JW-74 | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611635 | JW-74 | 1g | $1802 | 2021-12-16 | Buy |
| Cayman Chemical | 19124 | JW 74 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19124 | JW 74 ≥98% | 5mg | $110 | 2024-03-01 | Buy |
| Cayman Chemical | 19124 | JW 74 ≥98% | 10mg | $169 | 2024-03-01 | Buy |
| ChemScene | CS-5463 | JW74 99.45% | 5mg | $96 | 2021-12-16 | Buy |
| ChemScene | CS-5463 | JW74 99.45% | 10mg | $144 | 2021-12-16 | Buy |
| ChemScene | CS-5463 | JW74 99.45% | 25mg | $288 | 2021-12-16 | Buy |
| ChemScene | CS-5463 | JW74 99.45% | 50mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-5463 | JW74 99.45% | 100mg | $840 | 2021-12-16 | Buy |
| Crysdot | CD31000544 | JW74 98+% | 5mg | $55 | 2021-12-16 | Buy |
Properties
Boiling point :699.4±65.0 °C(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :1.63±0.10(Predicted)
form :powder
color :white to beige
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :1.63±0.10(Predicted)
form :powder
color :white to beige
Safety Information
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Description
Tankyrases (TNKS) are poly(ADP-ribose) polymerases (PARPs) that cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in a process known as poly(ADP-ribosyl)ation. TNKS have key roles in the Wnt signaling pathway as part of the β-catenin destruction complex. JW 74 is an inhibitor of the catalytic PARP domain of TNKS1/2 that blocks canonical Wnt signaling with an IC50 value of 790 nM. It increases the levels of Axin2 and decreases β-catenin levels in colorectal cancer (CRC) cells, leading to down-regulation of Wnt target genes. JW 74 inhibits the growth of CRC xenograft tumors in mice. JW 74 induces apoptosis and differentiation in osteosarcoma cell lines.Suppliers and manufacturers
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