KLH45
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- $32 - $1900
- Product name: KLH45
- CAS: 1632236-44-2
- MF: C24H25F3N4O2
- MW: 458.48
- EINECS:
- MDL Number:MFCD30742935
- Synonyms:KLH45;N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide;KLH45 >=98% (HPLC);2H-1,2,3-Triazole-2-carboxamide, N-cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-
12 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- DC Chemicals
- Tocris
- TRC
Package
- 10
- 1mg
- 5mg
- 50
- 10mg
- 25mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number4341EJ
- Product descriptionN-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]triazole-2-carboxamide
- Packaging25mg
- Price$505
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19889
- Product descriptionKLH45
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19889
- Product descriptionKLH45
- Packaging5mg
- Price$120
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19889
- Product descriptionKLH45
- Packaging10mg
- Price$178
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19889
- Product descriptionKLH45
- Packaging25mg
- Price$365
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0023744
- Product descriptionKLH45 ≥98.0%
- Packaging5mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0023744
- Product descriptionKLH45 ≥98.0%
- Packaging10mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC34244
- Product descriptionKLH45
- Packaging1g
- Price$1900
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC34244
- Product descriptionKLH45
- Packaging250mg
- Price$950
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number5865
- Product descriptionKLH45 ≥98%(HPLC)
- Packaging10
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number5865
- Product descriptionKLH45 ≥98%(HPLC)
- Packaging50
- Price$704
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberK571213
- Product descriptionKLH45
- Packaging10mg
- Price$315
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4341EJ | N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]triazole-2-carboxamide | 25mg | $505 | 2021-12-16 | Buy |
| Cayman Chemical | 19889 | KLH45 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19889 | KLH45 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 19889 | KLH45 | 10mg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 19889 | KLH45 | 25mg | $365 | 2024-03-01 | Buy |
| ChemScene | CS-0023744 | KLH45 ≥98.0% | 5mg | $200 | 2021-12-16 | Buy |
| ChemScene | CS-0023744 | KLH45 ≥98.0% | 10mg | $330 | 2021-12-16 | Buy |
| DC Chemicals | DC34244 | KLH45 | 1g | $1900 | 2021-12-16 | Buy |
| DC Chemicals | DC34244 | KLH45 | 250mg | $950 | 2021-12-16 | Buy |
| Tocris | 5865 | KLH45 ≥98%(HPLC) | 10 | $168 | 2021-12-16 | Buy |
| Tocris | 5865 | KLH45 ≥98%(HPLC) | 50 | $704 | 2021-12-16 | Buy |
| TRC | K571213 | KLH45 | 10mg | $315 | 2021-12-16 | Buy |
Properties
Boiling point :561.0±60.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
solubility :DMSO:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);65.43(Max Conc. mM) form :Solid-Liquid Mixture
pka :-1.76±0.20(Predicted)
color :Off-white to light yellow
Density :1.29±0.1 g/cm3(Predicted)
solubility :DMSO:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);65.43(Max Conc. mM) form :Solid-Liquid Mixture
pka :-1.76±0.20(Predicted)
color :Off-white to light yellow
Safety Information
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| Signal word: | Danger | ||||||||||||||||||||||||||||||
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Description
KLH45 is an inhibitor of the phospholipase DDHD domain containing 2 (DDHD2; IC50 = 1.3 nM). It is selective for DDHD2 over greater than 50 serine hydrolases, including DDHD1 and Sec23ip, but does inhibit α/β-hydrolase domain-containing protein 6 (ABHD6). It inhibits DDHD2 and ABHD6 in Neuro2A cells when used at a concentration of less than 10 nM and inhibits DDHD2 by greater than 95% at a concentration of 25 nM. KLH45 (2 μM) prevents increases in triacylglycerol (TAG) hydrolase activity in HEK293T cell lysates expressing recombinant DDHD2 and incubated with a radiolabeled TAG substrate. It decreases TAG levels in the CNS of mice when administered at a dose of 20 mg/kg twice per day for four days. KLH45 (2 μM) also reverses DDHD2-induced lipid droplet reduction in COS-7 cells expressing recombinant DDHD2 and loaded with oleic acid.Suppliers and manufacturers
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