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ChemicalBook >> CAS DataBase List >> LAS101057

LAS101057

LAS101057 price.
  • $62 - $495
  • Product name: LAS101057
  • CAS: 925676-48-8
  • MF: C18H14FN5O
  • MW: 335.34
  • EINECS:
  • MDL Number:
  • Synonyms:LAS101057;N-[5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide;N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide(WXFC0500);Cyclopropanecarboxamide, N-[5-(3-fluoro-4-pyridinyl)-6-(3-pyridinyl)-2-pyrazinyl]-;LAS-101057,LAS101057
Price9 Properties Safety Information Description
9 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Chemenu
  • ChemScene
Package
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number2229CW
  • Product descriptionCID16071896
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013975
  • Product descriptionLAS-101057 95.00%
  • Packaging5MG
  • Price$495
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number28435
  • Product descriptionLAS101057
  • Packaging5mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28435
  • Product descriptionLAS101057
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28435
  • Product descriptionLAS101057
  • Packaging25mg
  • Price$254
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28435
  • Product descriptionLAS101057
  • Packaging50mg
  • Price$477
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM334936
  • Product descriptionN-(5-(3-Fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide 95%+
  • Packaging100mg
  • Price$243
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6718
  • Product descriptionLAS101057 99.78%
  • Packaging5mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6718
  • Product descriptionLAS101057 99.78%
  • Packaging10mg
  • Price$270
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2229CW CID16071896 10mg $218 2021-12-16 Buy
American Custom Chemicals Corporation API0013975 LAS-101057 95.00% 5MG $495 2021-12-16 Buy
Cayman Chemical 28435 LAS101057 5mg $62 2024-03-01 Buy
Cayman Chemical 28435 LAS101057 10mg $109 2024-03-01 Buy
Cayman Chemical 28435 LAS101057 25mg $254 2024-03-01 Buy
Cayman Chemical 28435 LAS101057 50mg $477 2024-03-01 Buy
Chemenu CM334936 N-(5-(3-Fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide 95%+ 100mg $243 2021-12-16 Buy
ChemScene CS-6718 LAS101057 99.78% 5mg $160 2021-12-16 Buy
ChemScene CS-6718 LAS101057 99.78% 10mg $270 2021-12-16 Buy

Properties

Boiling point :509.2±50.0 °C(Predicted)
Density :1.400±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:125.0(Max Conc. mg/mL);372.75(Max Conc. mM)
form :A solid
pka :11.70±0.20(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

LAS 101057 is a potent, selective, and orally efficacious A2B receptor antagonist, was identified as a clinical development candidate. It inhibits agonist-induced IL-6 production in human fibroblasts and is active in an ovalbumin (OVA)-sensitized mouse model after oral administration, reducing airway hyperresponsiveness to methacholine, Th2 cytokine production and OVA-specific IgE levels.

Suppliers and manufacturers

Fuxin Pharmaceutical
TargetMol Chemicals Inc.
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific MedChemexpress LLC Shanghai Balmxy Pharmaceutical Co., Ltd Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. Shanghai EFE Biological Technology Co., Ltd. Shanghai ZiHao Pharmaceutical Co., Ltd. Cool Pharm, Ltd