LDN-57444
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- $32 - $2245.7
- Product name: LDN-57444
- CAS: 668467-91-2
- MF: C17H11Cl3N2O3
- MW: 397.64
- EINECS:
- MDL Number:MFCD09037562
- Synonyms:LDN-57444;5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione3-(O-acetyloxime);LDN-57444/LDN57444;1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime);5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) LDN 57444;3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione;UCH-L1 Inhibitor;(Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
43 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 50
- 1MG
- 10
- 10mg
- 25mg
- 50mg
- 100mg
- 10mM(in 1mL DMSO)
- 250mg
- 1000mg
- 1g
- ManufacturerAK Scientific
- Product number2511AH
- Product description3-(o-Acetyloxime),5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione
- Packaging25mg
- Price$342
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2511AH
- Product description3-(o-Acetyloxime),5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione
- Packaging100mg
- Price$772
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA388744
- Product description3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+%
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA388744
- Product description3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+%
- Packaging10mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA388744
- Product description3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+%
- Packaging25mg
- Price$155
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA388744
- Product description3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+%
- Packaging50mg
- Price$233
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA388744
- Product description3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+%
- Packaging100mg
- Price$352
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA388744
- Product description3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+%
- Packaging250mg
- Price$475
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA388744
- Product description3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+%
- Packaging1g
- Price$1045
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000990
- Product descriptionLDN-57444 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000990
- Product descriptionLDN-57444 95.00%
- Packaging5MG
- Price$659.4
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000990
- Product descriptionLDN-57444 95.00%
- Packaging25MG
- Price$880.46
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4003
- Product descriptionLDN57444
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4003
- Product descriptionLDN57444
- Packaging10mM(in 1mL DMSO)
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4003
- Product descriptionLDN57444
- Packaging50mg
- Price$304
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2449
- Product descriptionLDN57444 99%
- Packaging50mg
- Price$368.5
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2511AH | 3-(o-Acetyloxime),5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione | 25mg | $342 | 2021-12-16 | Buy |
| AK Scientific | 2511AH | 3-(o-Acetyloxime),5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione | 100mg | $772 | 2021-12-16 | Buy |
| Ambeed | A388744 | 3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+% | 5mg | $70 | 2021-12-16 | Buy |
| Ambeed | A388744 | 3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+% | 10mg | $104 | 2021-12-16 | Buy |
| Ambeed | A388744 | 3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+% | 25mg | $155 | 2021-12-16 | Buy |
| Ambeed | A388744 | 3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+% | 50mg | $233 | 2021-12-16 | Buy |
| Ambeed | A388744 | 3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+% | 100mg | $352 | 2021-12-16 | Buy |
| Ambeed | A388744 | 3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+% | 250mg | $475 | 2021-12-16 | Buy |
| Ambeed | A388744 | 3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one 98+% | 1g | $1045 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000990 | LDN-57444 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000990 | LDN-57444 95.00% | 5MG | $659.4 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000990 | LDN-57444 95.00% | 25MG | $880.46 | 2021-12-16 | Buy |
| ApexBio Technology | A4003 | LDN57444 | 10mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A4003 | LDN57444 | 10mM(in 1mL DMSO) | $105 | 2021-12-16 | Buy |
| ApexBio Technology | A4003 | LDN57444 | 50mg | $304 | 2021-12-16 | Buy |
| Axon Medchem | Axon2449 | LDN57444 99% | 50mg | $368.5 | 2021-12-16 | Buy |
Properties
Boiling point :534.4±60.0 °C(Predicted)
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble16mg/mL
form :solid
pka :-2.57±0.20(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble16mg/mL
form :solid
pka :-2.57±0.20(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Safety Information
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Description
The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson’s disease, the development of tumors, and neuropathic pain. LDN-57444 is an inhibitor of UCH-L1 activity (IC50 = 0.88, Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM). Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons.More related product prices
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