LY2801653
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- $62 - $3627
- Product name: LY2801653
- CAS: 1206799-15-6
- MF: C30H22F2N6O3
- MW: 552.53
- EINECS:806-589-8
- MDL Number:MFCD23160048
- Synonyms:LY2801653;N-(3-fluoro-4-((1-Methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxaMide;N-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxamide;Merestinib;LY2801653(Merestinib);N-(3-Fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-;Merestinib(LY 2801653);N-[3-fluoro-4-[1-methyl-6-(1h-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide
22 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
Package
- 5mg
- 10mM(in 1mL DMSO)
- 1mg
- 10mg
- 50mg
- 100mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1222-M010
- Product descriptionLY2801653 ≥95%
- Packaging10mg
- Price$292
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1222-M050
- Product descriptionLY2801653 ≥95%
- Packaging50mg
- Price$810
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1222
- Product descriptionLY2801653
- Packaging50mg
- Price$770
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3797AH
- Product descriptionN-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxamide
- Packaging1g
- Price$3627
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3573
- Product descriptionLY2801653
- Packaging5mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3573
- Product descriptionLY2801653
- Packaging10mM(in 1mL DMSO)
- Price$146
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3573
- Product descriptionLY2801653
- Packaging10mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3573
- Product descriptionLY2801653
- Packaging50mg
- Price$612
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3573
- Product descriptionLY2801653
- Packaging100mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25978
- Product descriptionLY2801653 ≥98%
- Packaging1mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25978
- Product descriptionLY2801653 ≥98%
- Packaging5mg
- Price$180
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25978
- Product descriptionLY2801653 ≥98%
- Packaging10mg
- Price$330
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25978
- Product descriptionLY2801653 ≥98%
- Packaging50mg
- Price$893
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM150825
- Product descriptionN-(3-Fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide 98%
- Packaging100mg
- Price$655
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1192
- Product descriptionMerestinib 99.99%
- Packaging5mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1192
- Product descriptionMerestinib 99.99%
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1222-M010 | LY2801653 ≥95% | 10mg | $292 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1222-M050 | LY2801653 ≥95% | 50mg | $810 | 2021-12-16 | Buy |
| AK Scientific | SYN1222 | LY2801653 | 50mg | $770 | 2021-12-16 | Buy |
| AK Scientific | 3797AH | N-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxamide | 1g | $3627 | 2021-12-16 | Buy |
| ApexBio Technology | A3573 | LY2801653 | 5mg | $126 | 2021-12-16 | Buy |
| ApexBio Technology | A3573 | LY2801653 | 10mM(in 1mL DMSO) | $146 | 2021-12-16 | Buy |
| ApexBio Technology | A3573 | LY2801653 | 10mg | $200 | 2021-12-16 | Buy |
| ApexBio Technology | A3573 | LY2801653 | 50mg | $612 | 2021-12-16 | Buy |
| ApexBio Technology | A3573 | LY2801653 | 100mg | $900 | 2021-12-16 | Buy |
| Cayman Chemical | 25978 | LY2801653 ≥98% | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 25978 | LY2801653 ≥98% | 5mg | $180 | 2024-03-01 | Buy |
| Cayman Chemical | 25978 | LY2801653 ≥98% | 10mg | $330 | 2024-03-01 | Buy |
| Cayman Chemical | 25978 | LY2801653 ≥98% | 50mg | $893 | 2024-03-01 | Buy |
| Chemenu | CM150825 | N-(3-Fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide 98% | 100mg | $655 | 2021-12-16 | Buy |
| ChemScene | CS-1192 | Merestinib 99.99% | 5mg | $132 | 2021-12-16 | Buy |
| ChemScene | CS-1192 | Merestinib 99.99% | 10mg | $180 | 2021-12-16 | Buy |
Properties
Boiling point :795.3±60.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥27.65 mg/mL in DMSO; insoluble in H2O; ≥5.02 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :10.83±0.70(Predicted)
color :White to yellow
InChIKey :QHADVLVFMKEIIP-UHFFFAOYSA-N
SMILES :C1(=O)N(C2=CC=C(F)C=C2)C(C)=CC=C1C(NC1=CC=C(OC2C(C3=CNN=C3)=CC3=C(C=2)C=NN3C)C(F)=C1)=O
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥27.65 mg/mL in DMSO; insoluble in H2O; ≥5.02 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :10.83±0.70(Predicted)
color :White to yellow
InChIKey :QHADVLVFMKEIIP-UHFFFAOYSA-N
SMILES :C1(=O)N(C2=CC=C(F)C=C2)C(C)=CC=C1C(NC1=CC=C(OC2C(C3=CNN=C3)=CC3=C(C=2)C=NN3C)C(F)=C1)=O
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||||||||||||||||
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Description
LY2801653 is an orally bioavailable MET kinase inhibitor (Ki = 2 nM). It also inhibits MST1R, Axl, MNK1/2, FLT3, DDR1, and DDR2 (IC50s = 11, 2, 7, 7, 0.1, and 7 nM, respectively, in a cell-based assay). It inhibits MET autophosphorylation stimulated by hepatocyte growth factor (HGF) in H460 and S114 cells (IC50s = 35.2 and 59.2 nM, respectively) and inhibits growth of Ba/F3 cells transfected with MET-activating mutations (IC50s = 12-248 nM). LY2801653 (0.01-10 μM) completely blocks cell scattering induced by HGF in DU145 cells. It reduces tumor growth in MET autocrine (U-87MG) and MET over-expression (H441) mouse xenograft models when administered at doses of 4 and 12 mg/kg.More related product prices
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