Lestaurtinib
|
- $44 - $1200
- Product name: Lestaurtinib
- CAS: 111358-88-4
- MF: C26H21N3O4
- MW: 439.47
- EINECS:
- MDL Number:MFCD09840836
- Synonyms:lestaurtinib;(9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one;SPM-924;CEP-701 hydrate;KT-5555 hydrate;Lestaurtinib hydrate; A 154475.0;(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:321kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
27 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1ug
- 50
- 500μg
- 500ug
- 1
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- ManufacturerAK Scientific
- Product numberV0246
- Product descriptionLestaurtinib
- Packaging1mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberV0246
- Product descriptionLestaurtinib
- Packaging5mg
- Price$266
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001285
- Product descriptionCEP-701 HYDRATE 95.00%
- Packaging1MG
- Price$674.9
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001285
- Product descriptionCEP-701 HYDRATE 95.00%
- Packaging5MG
- Price$1113.6
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4513
- Product descriptionLestaurtinib
- Packaging1mg
- Price$385
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIL2000
- Product descriptionLestaurtinib
- Packaging1mg
- Price$209
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIL2000
- Product descriptionLestaurtinib
- Packaging5mg
- Price$666
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIL2000
- Product descriptionLestaurtinib
- Packaging10mg
- Price$1156
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL24870
- Product descriptionLestaurtinib
- Packaging1mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL24870
- Product descriptionLestaurtinib
- Packaging1ug
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL24870
- Product descriptionLestaurtinib
- Packaging5mg
- Price$325
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL24870
- Product descriptionLestaurtinib
- Packaging10mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL24870
- Product descriptionLestaurtinib
- Packaging25mg
- Price$875
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL24870
- Product descriptionLestaurtinib
- Packaging50mg
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL24870
- Product descriptionLestaurtinib
- Packaging50
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number12094
- Product descriptionLestaurtinib ≥98%
- Packaging500μg
- Price$44
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | V0246 | Lestaurtinib | 1mg | $175 | 2021-12-16 | Buy |
| AK Scientific | V0246 | Lestaurtinib | 5mg | $266 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001285 | CEP-701 HYDRATE 95.00% | 1MG | $674.9 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001285 | CEP-701 HYDRATE 95.00% | 5MG | $1113.6 | 2021-12-16 | Buy |
| ApexBio Technology | A4513 | Lestaurtinib | 1mg | $385 | 2021-12-16 | Buy |
| Apolloscientific | BIL2000 | Lestaurtinib | 1mg | $209 | 2021-12-16 | Buy |
| Apolloscientific | BIL2000 | Lestaurtinib | 5mg | $666 | 2021-12-16 | Buy |
| Apolloscientific | BIL2000 | Lestaurtinib | 10mg | $1156 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL24870 | Lestaurtinib | 1mg | $130 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL24870 | Lestaurtinib | 1ug | $130 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL24870 | Lestaurtinib | 5mg | $325 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL24870 | Lestaurtinib | 10mg | $500 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL24870 | Lestaurtinib | 25mg | $875 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL24870 | Lestaurtinib | 50mg | $1200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL24870 | Lestaurtinib | 50 | $1200 | 2021-12-16 | Buy |
| Cayman Chemical | 12094 | Lestaurtinib ≥98% | 500μg | $44 | 2024-03-01 | Buy |
Properties
Melting point :215-220°C
Boiling point :723.0±60.0 °C(Predicted)
Density :1.70±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :white powder
pka :13.37±0.40(Predicted)
color :White or off-white
Stability :Photosensitive
Boiling point :723.0±60.0 °C(Predicted)
Density :1.70±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :white powder
pka :13.37±0.40(Predicted)
color :White or off-white
Stability :Photosensitive
Safety Information
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Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative disorders. Lestaurtinib is a staurosporine analog that potently inhibits JAK2 kinase (IC50 = 1 nM) and downstream targets STAT5 (IC50 = 10-30 nM) and STAT3 in a human erythroleukemic cell line expressing the JAK2V617F mutation. It has been used to reduce tumor growth in a xenograft model of pancreatic ductal adenocarcinoma, to inhibit cell growth in a trk-B overexpressing neuroblastoma xenograft model, and to block proliferation and induce apoptosis in Hodgkin lymphoma cell lines. Lestaurtinib has since been reported to potently inhibit the epigenetic kinase PRK1 in vitro (IC50 = 8.6 nM), inducing hypophosphorylation of histone H3 threonine 11 and blocking androgen-dependent gene expression in prostate cancer cells at a concentration of 5 μM.Related product price
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