MANUMYCIN A
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- $111 - $1580
- Product name: MANUMYCIN A
- CAS: 52665-74-4
- MF: C31H38N2O7
- MW: 550.64
- EINECS:
- MDL Number:MFCD18432704
- Synonyms:MANUMYCIN A;MANUMYCIN A, STREPTOMYCES PARVULUS;N-[5-Hydroxy-5-[7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide;manumycin ;manumycin A from streptomyces parvulus;NSC 622141;UCF 1C;(2E,4E)-N-[(5R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide
17 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 0.5mg
- 1mg
- 2.5mg
- 5MG
- 10mg
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0091-M010
- Product descriptionManumycin A, ≥98%(HPLC)
- Packaging10mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1846AH
- Product descriptionManumycin A,
- Packaging1mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0003254
- Product descriptionMANUMYCIN 95.00%
- Packaging1MG
- Price$518
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0003254
- Product descriptionMANUMYCIN 95.00%
- Packaging5MG
- Price$990
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0003254
- Product descriptionMANUMYCIN 95.00%
- Packaging10MG
- Price$1580
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6062
- Product descriptionManumycin A,
- Packaging1mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6062
- Product descriptionManumycin A,
- Packaging5mg
- Price$442
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546100
- Product descriptionManumycin A >98%
- Packaging1mg
- Price$244.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546100
- Product descriptionManumycin A >98%
- Packaging5mg
- Price$720.8
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10010497
- Product descriptionManumycin A ≥98%
- Packaging1mg
- Price$111
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10010497
- Product descriptionManumycin A ≥98%
- Packaging5mg
- Price$412
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0100050
- Product descriptionManumycin A,
- Packaging5mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number47166
- Product descriptionManumycin A,
- Packaging2.5mg
- Price$1475
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberM6418
- Product descriptionManumycin A from Streptomyces parvulus
- Packaging5mg
- Price$781
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberM186000
- Product descriptionManumycin A,
- Packaging0.5mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number207273
- Product descriptionManumycin A
- Packaging1mg
- Price$325
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | BVT-0091-M010 | Manumycin A, ≥98%(HPLC) | 10mg | $650 | 2021-12-16 | Buy |
| AK Scientific | 1846AH | Manumycin A, | 1mg | $221 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003254 | MANUMYCIN 95.00% | 1MG | $518 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003254 | MANUMYCIN 95.00% | 5MG | $990 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003254 | MANUMYCIN 95.00% | 10MG | $1580 | 2021-12-16 | Buy |
| ApexBio Technology | B6062 | Manumycin A, | 1mg | $118 | 2021-12-16 | Buy |
| ApexBio Technology | B6062 | Manumycin A, | 5mg | $442 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546100 | Manumycin A >98% | 1mg | $244.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546100 | Manumycin A >98% | 5mg | $720.8 | 2021-12-16 | Buy |
| Cayman Chemical | 10010497 | Manumycin A ≥98% | 1mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 10010497 | Manumycin A ≥98% | 5mg | $412 | 2024-03-01 | Buy |
| ChemScene | CS-0100050 | Manumycin A, | 5mg | $800 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 47166 | Manumycin A, | 2.5mg | $1475 | 2021-12-16 | Buy |
| Sigma-Aldrich | M6418 | Manumycin A from Streptomyces parvulus | 5mg | $781 | 2024-03-01 | Buy |
| TRC | M186000 | Manumycin A, | 0.5mg | $225 | 2021-12-16 | Buy |
| Usbiological | 207273 | Manumycin A | 1mg | $325 | 2021-12-16 | Buy |
Properties
Boiling point :863.6±65.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 10 mg/ml), in Ethanol (up to 5 mg/ml) or in DMF (up to 20 mg/ml)
pka :3.80±0.30(Predicted)
form :Yellow to brown solid
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or DMF may be stored at -20°C for up to 3 months.
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 10 mg/ml), in Ethanol (up to 5 mg/ml) or in DMF (up to 20 mg/ml)
pka :3.80±0.30(Predicted)
form :Yellow to brown solid
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or DMF may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||
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Description
Manumycin A is an antibiotic originally generated by Streptomyces parvulus that acts as a selective and vigorous inhibitor of Ras farnesyltransferase. The compound has been observed to block the activity of IKKβ by robustly and rapidly inhibiting TNF alpha induced phosphorylation of IκBα and NF-κB nuclear translocation. Studies indicate that Manumycin A has the ability to induce the dimerization of IKKβ and dissociation of IKK from IKKγ/NEMO, the adapter protein. Atherosclerosis studies report that Manumycin A decreases oxidative stress. Additionally, Manumycin A irreversibly inhibits neutral sphingomyelina, and has been shown to produce nitric oxide and induce apoptosis in leukemia cell studies. Manumycin A is an inhibitor of Farnesyl Transferase and N-SMase.Related product price
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