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ChemicalBook >> CAS DataBase List >> MGL-3196

MGL-3196

MGL-3196 price.
  • $44 - $1900
  • Product name: MGL-3196
  • CAS: 920509-32-6
  • MF: C17H12Cl2N6O4
  • MW: 435.22
  • EINECS:
  • MDL Number:MFCD26142653
  • Synonyms:MGL-3196;Resmetirom (MGL-3196,VIA-3196);MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196;VIA3196;VIA-3196;2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile;CS-2429;1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-
Price20 Properties Safety Information Description
20 prices
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Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Crysdot
  • CSNpharm
  • DC Chemicals
Package
  • 1mg
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  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
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  • 1g
  • ManufacturerAmbeed
  • Product numberA679714
  • Product description2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+%
  • Packaging2mg
  • Price$46
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA679714
  • Product description2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA679714
  • Product description2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+%
  • Packaging10mg
  • Price$78
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA679714
  • Product description2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+%
  • Packaging25mg
  • Price$102
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA679714
  • Product description2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+%
  • Packaging50mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA679714
  • Product description2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+%
  • Packaging100mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA679714
  • Product description2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+%
  • Packaging250mg
  • Price$272
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA679714
  • Product description2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+%
  • Packaging1g
  • Price$690
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0018402
  • Product descriptionMGL-3196 95.00%
  • Packaging5MG
  • Price$505.57
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23845
  • Product descriptionMGL-3196 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23845
  • Product descriptionMGL-3196 ≥98%
  • Packaging5mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23845
  • Product descriptionMGL-3196 ≥98%
  • Packaging10mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00000577
  • Product descriptionMGL-3196 98+%
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00000577
  • Product descriptionMGL-3196 98+%
  • Packaging50mg
  • Price$480
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00000577
  • Product descriptionMGL-3196 98+%
  • Packaging100mg
  • Price$735
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN19099
  • Product descriptionMGL-3196
  • Packaging2mg
  • Price$56
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A679714 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+% 2mg $46 2021-12-16 Buy
Ambeed A679714 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+% 5mg $60 2021-12-16 Buy
Ambeed A679714 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+% 10mg $78 2021-12-16 Buy
Ambeed A679714 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+% 25mg $102 2021-12-16 Buy
Ambeed A679714 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+% 50mg $132 2021-12-16 Buy
Ambeed A679714 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+% 100mg $185 2021-12-16 Buy
Ambeed A679714 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+% 250mg $272 2021-12-16 Buy
Ambeed A679714 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 99+% 1g $690 2021-12-16 Buy
American Custom Chemicals Corporation API0018402 MGL-3196 95.00% 5MG $505.57 2021-12-16 Buy
Cayman Chemical 23845 MGL-3196 ≥98% 1mg $44 2024-03-01 Buy
Cayman Chemical 23845 MGL-3196 ≥98% 5mg $193 2024-03-01 Buy
Cayman Chemical 23845 MGL-3196 ≥98% 10mg $341 2024-03-01 Buy
Crysdot CD00000577 MGL-3196 98+% 10mg $175 2021-12-16 Buy
Crysdot CD00000577 MGL-3196 98+% 50mg $480 2021-12-16 Buy
Crysdot CD00000577 MGL-3196 98+% 100mg $735 2021-12-16 Buy
CSNpharm CSN19099 MGL-3196 2mg $56 2021-12-16 Buy
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Properties

Density :1.65±0.1 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO:59.0(Max Conc. mg/mL);135.56(Max Conc. mM)
form :A crystalline solid
pka :3.96±0.40(Predicted)
color :Yellow to orange
InChI :InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)
InChIKey :FDBYIYFVSAHJLY-UHFFFAOYSA-N
SMILES :N1=C(C#N)C(=O)NC(=O)N1C1=CC(Cl)=C(OC2=NNC(=O)C(C(C)C)=C2)C(Cl)=C1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MGL-3196 is an agonist of thyroid hormone receptor β (TRβ; EC50s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC50 = 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure. It does not affect the expression of α-myosin heavy chain (α-MHC) in a rat model of hypothyroidism, an effect mediated by TRα, indicating low potential for cardiac adverse effects. MGL-3196 lowers non-HDL cholesterol and liver triglycerides without affecting thyroid stimulating hormone (Tsh) levels in rat and rabbit models of hypercholesterolemia. It also lowers plasma glucose levels and improves insulin sensitivity in DIO mice. Formulations containing MGL-3196 are in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) and familial hypercholesterolemia.

Suppliers and manufacturers

Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Jinan Carbotang Biotech Co.,Ltd.
BOC Sciences
Career Henan Chemica Co
Chemia Biotechnology（Shanghai） Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
Nextpeptide Inc
InvivoChem
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.