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ChemicalBook >> CAS DataBase List >> MK2-IN-1 (hydrochloride)

MK2-IN-1 (hydrochloride)

MK2-IN-1 (hydrochloride) price.
  • $65 - $1800
  • Product name: MK2-IN-1 (hydrochloride)
  • CAS: 1314118-94-9
  • MF: C27H26Cl2N4O2
  • MW: 509.43
  • EINECS:
  • MDL Number:MFCD29472226
  • Synonyms:MK2-IN-1 (hydrochloride);MK2 Inhibitor IV;MK 25 (hydrochloride);MK2 inhibitor 1 hydrochloride;MK 25;5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride[MK2 Inhibitor Hydrochloride];5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride;inhibit,MAP kinase activated protein kinase 2,MAPK activated protein kinase 2,MAPKAPK2 (MK2),Inhibitor,MK2IN1 hydrochloride,MK2 IN 1 hydrochloride,MAPKAP kinase 2,MK-2-IN-1 hydrochloride,Mitogen-activated protein kinase activated protein kinase 2
Price22 Properties Safety Information Description
22 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
Package
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number1740DU
  • Product descriptionMK2-IN-1hydrochloride
  • Packaging50mg
  • Price$417
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1740DU
  • Product descriptionMK2-IN-1hydrochloride
  • Packaging100mg
  • Price$552
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA790720
  • Product descriptionMK2-IN-1hydrochloride 98+%
  • Packaging2mg
  • Price$73
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA790720
  • Product descriptionMK2-IN-1hydrochloride 98+%
  • Packaging5mg
  • Price$169
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA790720
  • Product descriptionMK2-IN-1hydrochloride 98+%
  • Packaging10mg
  • Price$233
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA790720
  • Product descriptionMK2-IN-1hydrochloride 98+%
  • Packaging25mg
  • Price$396
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5545
  • Product descriptionMK2InhibitorIV
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5545
  • Product descriptionMK2InhibitorIV
  • Packaging10mg
  • Price$134
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5545
  • Product descriptionMK2InhibitorIV
  • Packaging25mg
  • Price$317
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14399
  • Product descriptionMK2 Inhibitor IV ≥95%
  • Packaging5mg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14399
  • Product descriptionMK2 Inhibitor IV ≥95%
  • Packaging10mg
  • Price$152
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14399
  • Product descriptionMK2 Inhibitor IV ≥95%
  • Packaging25mg
  • Price$356
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4584
  • Product descriptionMK2-IN-1hydrochloride 99.19%
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4584
  • Product descriptionMK2-IN-1hydrochloride 99.19%
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4584
  • Product descriptionMK2-IN-1hydrochloride 99.19%
  • Packaging50mg
  • Price$480
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4584
  • Product descriptionMK2-IN-1hydrochloride 99.19%
  • Packaging100mg
  • Price$850
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1740DU MK2-IN-1hydrochloride 50mg $417 2021-12-16 Buy
AK Scientific 1740DU MK2-IN-1hydrochloride 100mg $552 2021-12-16 Buy
Ambeed A790720 MK2-IN-1hydrochloride 98+% 2mg $73 2021-12-16 Buy
Ambeed A790720 MK2-IN-1hydrochloride 98+% 5mg $169 2021-12-16 Buy
Ambeed A790720 MK2-IN-1hydrochloride 98+% 10mg $233 2021-12-16 Buy
Ambeed A790720 MK2-IN-1hydrochloride 98+% 25mg $396 2021-12-16 Buy
ApexBio Technology C5545 MK2InhibitorIV 5mg $70 2021-12-16 Buy
ApexBio Technology C5545 MK2InhibitorIV 10mg $134 2021-12-16 Buy
ApexBio Technology C5545 MK2InhibitorIV 25mg $317 2021-12-16 Buy
Cayman Chemical 14399 MK2 Inhibitor IV ≥95% 5mg $81 2024-03-01 Buy
Cayman Chemical 14399 MK2 Inhibitor IV ≥95% 10mg $152 2024-03-01 Buy
Cayman Chemical 14399 MK2 Inhibitor IV ≥95% 25mg $356 2024-03-01 Buy
ChemScene CS-4584 MK2-IN-1hydrochloride 99.19% 5mg $65 2021-12-16 Buy
ChemScene CS-4584 MK2-IN-1hydrochloride 99.19% 10mg $120 2021-12-16 Buy
ChemScene CS-4584 MK2-IN-1hydrochloride 99.19% 50mg $480 2021-12-16 Buy
ChemScene CS-4584 MK2-IN-1hydrochloride 99.19% 100mg $850 2021-12-16 Buy
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Properties

storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :insoluble in DMSO; ≥16.5 mg/mL in EtOH with ultrasonic; ≥37.4 mg/mL in H2O
form :A crystalline solid
color :Light yellow to pink

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Activation of the p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2) pathway has been implicated in promoting pro-inflammatory cytokine production and related inflammatory diseases. MK2 Inhibitor IV is a highly selective, non-ATP competitive MK2 inhibitor with an IC50 value of 0.11 μM. MK2 Inhibitor IV has been shown to inhibit pro-inflammatory cytokine secretion from the human THP-1 acute monocytic leukemia cell line, causing inhibition of LPS-stimulated TNF-α (IC50 = 4.4 μM) and IL-6 (IC50 = 5.2 μM) secretion. It can also inhibit IL-1β-stimulated matrixmetalloprotease 13 secretion from the SW1353 chondrosarcoma cell line (IC50 = 5.7 μM) and human primary chondrocyte cultures (IC50 = 2.2 μM).

Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
InvivoChem
TargetMol Chemicals Inc.
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
SHANGHAI KEAN TECHNOLOGY CO., LTD.
Amadis Chemical Company Limited Haoyuan Chemexpress Co., Ltd. Guangzhou QiYun Biotechnology Co., Ltd.