ML 351
|
- $56 - $901
- Product name: ML 351
- CAS: 847163-28-4
- MF: C15H11N3O
- MW: 249.27
- EINECS:
- MDL Number:MFCD04183120
- Synonyms:ML 351;5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile;4-Oxazolecarbonitrile, 5-(methylamino)-2-(1-naphthalenyl)-;Subarachnoid hemorrhage,inhibit,oxidative stress,ML-351,SAH,neuronal,Lipoxygenase,LOX,T1D,β-cell,ML 351,ML351,Inhibitor,non-obese diabetic;5-(Methylamino)-2-(naphthalen-1-yl)oxazole-4-carbonitrile
16 prices
Selected condition：
Brand
- A1 Biochem Labs
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5
- 1mg
- 5mg
- 25
- 25mg
- 1g
- 10 mg
- 25 mg
- ManufacturerA1 Biochem Labs
- Product number6581348
- Product description5-Methylamino-2-naphthalen-1-yl-oxazole-4-carbonitrile 95%
- Packaging1g
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9811CC
- Product description5-(Methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile
- Packaging5mg
- Price$307
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0003639
- Product descriptionML-351 98.00%
- Packaging5MG
- Price$505.34
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4277
- Product descriptionML351
- Packaging1mg
- Price$61
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4277
- Product descriptionML351
- Packaging5mg
- Price$214
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2312
- Product descriptionML351 98%
- Packaging5mg
- Price$137.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2312
- Product descriptionML351 98%
- Packaging25mg
- Price$467.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16119
- Product descriptionML351 ≥98%
- Packaging1mg
- Price$56
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16119
- Product descriptionML351 ≥98%
- Packaging5mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16119
- Product descriptionML-351 ≥98%
- Packaging10 mg
- Price$221
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16119
- Product descriptionML-351 ≥98%
- Packaging25 mg
- Price$483
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1353
- Product descriptionML351 ≥98% (HPLC)
- Packaging5MG
- Price$226
- Updated2023-06-20
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1353
- Product descriptionML351 ≥98% (HPLC)
- Packaging25MG
- Price$901
- Updated2023-06-20
- Buy
- ManufacturerTocris
- Product number6448
- Product descriptionML351 ≥98%(HPLC)
- Packaging5
- Price$167
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number6448
- Product descriptionML351 ≥98%(HPLC)
- Packaging25
- Price$649
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberM425478
- Product descriptionML351
- Packaging1mg
- Price$110
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A1 Biochem Labs | 6581348 | 5-Methylamino-2-naphthalen-1-yl-oxazole-4-carbonitrile 95% | 1g | $550 | 2021-12-16 | Buy |
| AK Scientific | 9811CC | 5-(Methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile | 5mg | $307 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0003639 | ML-351 98.00% | 5MG | $505.34 | 2021-12-16 | Buy |
| ApexBio Technology | C4277 | ML351 | 1mg | $61 | 2021-12-16 | Buy |
| ApexBio Technology | C4277 | ML351 | 5mg | $214 | 2021-12-16 | Buy |
| Axon Medchem | Axon2312 | ML351 98% | 5mg | $137.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2312 | ML351 98% | 25mg | $467.5 | 2021-12-16 | Buy |
| Cayman Chemical | 16119 | ML351 ≥98% | 1mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 16119 | ML351 ≥98% | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 16119 | ML-351 ≥98% | 10 mg | $221 | 2024-03-01 | Buy |
| Cayman Chemical | 16119 | ML-351 ≥98% | 25 mg | $483 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1353 | ML351 ≥98% (HPLC) | 5MG | $226 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1353 | ML351 ≥98% (HPLC) | 25MG | $901 | 2023-06-20 | Buy |
| Tocris | 6448 | ML351 ≥98%(HPLC) | 5 | $167 | 2021-12-16 | Buy |
| Tocris | 6448 | ML351 ≥98%(HPLC) | 25 | $649 | 2021-12-16 | Buy |
| TRC | M425478 | ML351 | 1mg | $110 | 2021-12-16 | Buy |
Properties
Boiling point :507.3±60.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :≤5mg/ml in DMSO;25mg/ml in dimethyl formamide
pka :-0.97±0.10(Predicted)
form :powder
color :white to beige
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :≤5mg/ml in DMSO;25mg/ml in dimethyl formamide
pka :-0.97±0.10(Predicted)
form :powder
color :white to beige
Safety Information
| Symbol(GHS): |
|
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||||
| Hazard statements: |
|
||||||||||||||||
| Precautionary statements: |
|
Description
Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides. The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer. ML351 is an inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2. ML351 was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.Suppliers and manufacturers
TargetMol Chemicals Inc.
LEAPCHEM CO., LTD.
Aladdin Scientific
BOC Sciences
Guangzhou Isun Pharmaceutical Co., Ltd
Sigma-Aldrich
Shanghai EFE Biological Technology Co., Ltd.
Tianjin Kailiqi Biotechnology Co., Ltd.
Shanghai Chaolan Chemical Technology Center
Beijing Solarbio Science & Tecnology Co., Ltd.