NBI-74330
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- $72 - $1420
- Product name: NBI-74330
- CAS: 855527-92-3
- MF: C32H27F4N5O3
- MW: 605.58
- EINECS:
- MDL Number:MFCD11850718
- Synonyms:NBI-74330;N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide;Benzeneacetamide, N-[(1R)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)-;(R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)acetamide
16 prices
Selected condition：
Brand
- Ambeed
- American Custom Chemicals Corporation
- Cayman Chemical
- ChemScene
- Crysdot
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAmbeed
- Product numberA468366
- Product descriptionNbi-74330 98+%
- Packaging1mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA468366
- Product descriptionNbi-74330 98+%
- Packaging5mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA468366
- Product descriptionNbi-74330 98+%
- Packaging10mg
- Price$207
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA468366
- Product descriptionNbi-74330 98+%
- Packaging25mg
- Price$378
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA468366
- Product descriptionNbi-74330 98+%
- Packaging50mg
- Price$711
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA468366
- Product descriptionNbi-74330 98+%
- Packaging100mg
- Price$1420
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000619
- Product descriptionNBI-74330 95.00%
- Packaging5MG
- Price$503.49
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28442
- Product descriptionNBI 74330
- Packaging1mg
- Price$359
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28442
- Product descriptionNBI 74330
- Packaging5mg
- Price$1253
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-2217
- Product descriptionNBI-74330 99.23%
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2217
- Product descriptionNBI-74330 99.23%
- Packaging10mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2217
- Product descriptionNBI-74330 99.23%
- Packaging25mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2217
- Product descriptionNBI-74330 99.23%
- Packaging50mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2217
- Product descriptionNBI-74330 99.23%
- Packaging100mg
- Price$1350
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000588
- Product descriptionNBI-74330 98+%
- Packaging5mg
- Price$525
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000588
- Product descriptionNBI-74330 98+%
- Packaging10mg
- Price$725
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A468366 | Nbi-74330 98+% | 1mg | $72 | 2021-12-16 | Buy |
| Ambeed | A468366 | Nbi-74330 98+% | 5mg | $126 | 2021-12-16 | Buy |
| Ambeed | A468366 | Nbi-74330 98+% | 10mg | $207 | 2021-12-16 | Buy |
| Ambeed | A468366 | Nbi-74330 98+% | 25mg | $378 | 2021-12-16 | Buy |
| Ambeed | A468366 | Nbi-74330 98+% | 50mg | $711 | 2021-12-16 | Buy |
| Ambeed | A468366 | Nbi-74330 98+% | 100mg | $1420 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000619 | NBI-74330 95.00% | 5MG | $503.49 | 2021-12-16 | Buy |
| Cayman Chemical | 28442 | NBI 74330 | 1mg | $359 | 2024-03-01 | Buy |
| Cayman Chemical | 28442 | NBI 74330 | 5mg | $1253 | 2024-03-01 | Buy |
| ChemScene | CS-2217 | NBI-74330 99.23% | 5mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-2217 | NBI-74330 99.23% | 10mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-2217 | NBI-74330 99.23% | 25mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-2217 | NBI-74330 99.23% | 50mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-2217 | NBI-74330 99.23% | 100mg | $1350 | 2021-12-16 | Buy |
| Crysdot | CD31000588 | NBI-74330 98+% | 5mg | $525 | 2021-12-16 | Buy |
| Crysdot | CD31000588 | NBI-74330 98+% | 10mg | $725 | 2021-12-16 | Buy |
Properties
Boiling point :752.5±70.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:100.0(Max Conc. mg/mL);165.1(Max Conc. mM)
pka :4?+-.0.11(Predicted)
form :Powder
color :Light yellow to yellow
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:100.0(Max Conc. mg/mL);165.1(Max Conc. mM)
pka :4?+-.0.11(Predicted)
form :Powder
color :Light yellow to yellow
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
NBI 74330 is a chemokine (C-X-C motif) receptor 3 (CXCR3) antagonist (Ki = 3.6 nM in a radioligand binding assay). It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 10 (CXCL10) or CXCL11 in RBL cells expressing human CXCR3 (IC50 = 7 nM for both). NBI 74330 inhibits CXCL11-induced chemotaxis of CXCR3-expressing H9 cells and PHA and IL-2 differentiated T cells (IC50s = 3.9 and 6.6 nM, respectively). In vivo, NBI 74330 (100 mg/kg) reduces peritoneal lymphocyte migration in a mouse model of peritonitis. It reduces the size and number of aortic arch atherosclerotic lesions in Ldlr-/- mice. NBI 74330 reduces spinal cord microglial activation and levels of CXCL4, CXCL9, and CXCL10 and decreases thermal and mechanical hyperalgesia in a rat model of chronic constriction injury-induced neuropathic pain.Related product price
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