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ChemicalBook >> CAS DataBase List >> NS8593 HYDROCHLORIDE

NS8593 HYDROCHLORIDE

NS8593 HYDROCHLORIDE price.
  • $29 - $2200
  • Product name: NS8593 HYDROCHLORIDE
  • CAS: 875755-24-1
  • MF: C17H17N3.ClH
  • MW: 299.803
  • EINECS:
  • MDL Number:MFCD11045298
  • Synonyms:NS8593 HYDROCHLORIDE;: N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride;NS8593;N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine;NS8593 HCl;NS8593 hydrochloride,inhibit,NS8593,neurological,Ca2+,Inhibitor,hIK,SK1,SK2,KcsA,Potassium Channel,NS-8593,SK3,hBK,neurons,NS-8593 hydrochloride,dopaminergic,NS 8593,channel
Price20 Properties Safety Information Description
20 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 003
  • 002
  • 1mg
  • 5mg
  • 50
  • 10
  • 10mg
  • 25mg
  • 50MG
  • 100mg
  • 500MG
  • 001
  • ManufacturerAK Scientific
  • Product number7084DU
  • Product descriptionNS8593 hydrochloride
  • Packaging1mg
  • Price$137
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0009871
  • Product descriptionNS8593 HYDROCHLORIDE 95.00%
  • Packaging50MG
  • Price$716.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0009871
  • Product descriptionNS8593 HYDROCHLORIDE 95.00%
  • Packaging500MG
  • Price$1686.3
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29774
  • Product descriptionNS 8593 (hydrochloride)
  • Packaging1mg
  • Price$29
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29774
  • Product descriptionNS 8593 (hydrochloride)
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29774
  • Product descriptionNS 8593 (hydrochloride)
  • Packaging10mg
  • Price$172
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29774
  • Product descriptionNS 8593 (hydrochloride)
  • Packaging25mg
  • Price$393
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0032958
  • Product descriptionNS8593 hydrochloride 99.88%
  • Packaging5mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0032958
  • Product descriptionNS8593 hydrochloride 99.88%
  • Packaging10mg
  • Price$195
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0032958
  • Product descriptionNS8593 hydrochloride 99.88%
  • Packaging25mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product number012318
  • Product descriptionNS8593 hydrochloride
  • Packaging001
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product number012318
  • Product descriptionNS8593 hydrochloride
  • Packaging002
  • Price$1100
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product number012318
  • Product descriptionNS8593 hydrochloride
  • Packaging003
  • Price$2200
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberN2538
  • Product descriptionNS8593 hydrochloride ≥98% (HPLC), powder
  • Packaging5mg
  • Price$169
  • Updated2022-05-15
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number492031
  • Product descriptionNS8593 An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner.
  • Packaging10MG
  • Price$196
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberN2538
  • Product descriptionNS8593 hydrochloride ≥98% (HPLC), powder
  • Packaging25mg
  • Price$638
  • Updated2022-05-15
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 7084DU NS8593 hydrochloride 1mg $137 2021-12-16 Buy
American Custom Chemicals Corporation API0009871 NS8593 HYDROCHLORIDE 95.00% 50MG $716.1 2021-12-16 Buy
American Custom Chemicals Corporation API0009871 NS8593 HYDROCHLORIDE 95.00% 500MG $1686.3 2021-12-16 Buy
Cayman Chemical 29774 NS 8593 (hydrochloride) 1mg $29 2024-03-01 Buy
Cayman Chemical 29774 NS 8593 (hydrochloride) 5mg $93 2024-03-01 Buy
Cayman Chemical 29774 NS 8593 (hydrochloride) 10mg $172 2024-03-01 Buy
Cayman Chemical 29774 NS 8593 (hydrochloride) 25mg $393 2024-03-01 Buy
ChemScene CS-0032958 NS8593 hydrochloride 99.88% 5mg $100 2021-12-16 Buy
ChemScene CS-0032958 NS8593 hydrochloride 99.88% 10mg $195 2021-12-16 Buy
ChemScene CS-0032958 NS8593 hydrochloride 99.88% 25mg $450 2021-12-16 Buy
DC Chemicals 012318 NS8593 hydrochloride 001 $650 2021-12-16 Buy
DC Chemicals 012318 NS8593 hydrochloride 002 $1100 2021-12-16 Buy
DC Chemicals 012318 NS8593 hydrochloride 003 $2200 2021-12-16 Buy
Sigma-Aldrich N2538 NS8593 hydrochloride ≥98% (HPLC), powder 5mg $169 2022-05-15 Buy
Sigma-Aldrich 492031 NS8593 An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner. 10MG $196 2024-03-01 Buy
Sigma-Aldrich N2538 NS8593 hydrochloride ≥98% (HPLC), powder 25mg $638 2022-05-15 Buy
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Properties

storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :powder
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:

Description

NS 8593 is an inhibitory gating modifier of small-conductance calcium-activated potassium (KCa2/SK) channels (Kds = 0.42, 0.6, and 0.73 μM for KCa2.1/SK1, KCa2.2/SK2, and KCa2.3/SK3, respectively, in the presence of calcium) that decreases the calcium sensitivity of SK channels. It is selective for KCa2/SK channels over intermediate- (KCa3.1/IKCa1) and large-conductance (BK) potassium channels at 10 μM. NS 8593 induces relaxation of potassium- or acetylcholine chloride-precontracted isolated tracheal rings from wild-type mice (IC50s = 8.9 and 39.8 μM, respectively) or from mice in an ovalbumin-induced model of allergic asthma (IC50s = 16.4 and 32.2 μM, respectively). It inhibits aerosolized acetylcholine chloride-induced increases in respiratory system resistance in mice when administered as an aerosol at a dose of 500 μM. NS 8593 (5 mg/kg) decreases the duration of burst-pacing-induced atrial fibrillation in normotensive and spontaneously hypertensive rats.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Nantong HI-FUTURE Biology Co., Ltd.
LEAPCHEM CO., LTD.
Aladdin Scientific Shanghai Rechem science Co., Ltd. Sigma-Aldrich Shanghai Lollane Biological Technology Co.,Ltd. Shanghai Hongye Biotechnology Co. Ltd DC Chemicals Changzhou Chenhong Biotechnology Co., Ltd.