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ChemicalBook >> CAS DataBase List >> Necrostatin-5

Necrostatin-5

Necrostatin-5 price.
  • $49 - $337
  • Product name: Necrostatin-5
  • CAS: 337349-54-9
  • MF: C19H17N3O2S2
  • MW: 383.49
  • EINECS:
  • MDL Number:MFCD01448275
  • Synonyms:Necrostatin-5;Necrostatin-5 (Nec-5);2-[[3,4,5,6,7,8-Hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile;3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide;Acetonitrile, 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-;Necrostatin-5 >=98% (HPLC), solid;Necrostatin5,Necrostatin 5;2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile
Price8 Properties Safety Information Description
8 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Cayman Chemical
  • Sigma-Aldrich
  • Usbiological
Package
  • 5mg
  • 25mg
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0049-M025
  • Product descriptionNecrostatin-5 ≥98%(NMR)
  • Packaging25mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number9562BA
  • Product descriptionNecrostatin-5
  • Packaging25mg
  • Price$337
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10527
  • Product descriptionNecrostatin-5 ≥98%
  • Packaging5mg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10527
  • Product descriptionNecrostatin-5 ≥98%
  • Packaging25mg
  • Price$216
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberN0164
  • Product descriptionNecrostatin-5 ≥98% (HPLC), solid
  • Packaging5mg
  • Price$90.5
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberN0164
  • Product descriptionNecrostatin-5 ≥98% (HPLC), solid
  • Packaging25mg
  • Price$320
  • Updated2022-05-15
  • Buy
  • ManufacturerUsbiological
  • Product number045074
  • Product descriptionNecrostatin-5
  • Packaging5mg
  • Price$282
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product numberN0571-30
  • Product descriptionNecrostatin-5
  • Packaging5mg
  • Price$286
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-0049-M025 Necrostatin-5 ≥98%(NMR) 25mg $160 2021-12-16 Buy
AK Scientific 9562BA Necrostatin-5 25mg $337 2021-12-16 Buy
Cayman Chemical 10527 Necrostatin-5 ≥98% 5mg $49 2024-03-01 Buy
Cayman Chemical 10527 Necrostatin-5 ≥98% 25mg $216 2024-03-01 Buy
Sigma-Aldrich N0164 Necrostatin-5 ≥98% (HPLC), solid 5mg $90.5 2024-03-01 Buy
Sigma-Aldrich N0164 Necrostatin-5 ≥98% (HPLC), solid 25mg $320 2022-05-15 Buy
Usbiological 045074 Necrostatin-5 5mg $282 2021-12-16 Buy
Usbiological N0571-30 Necrostatin-5 5mg $286 2021-12-16 Buy

Properties

Melting point :212-214℃
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :solid
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
Necrostatin-5
$0.00 /50mg
Necrostatin-5 CAS:337349-54-9
Aladdin Scientific Shanghai Tauto Biotech Co., Ltd. Shanghai EFE Biological Technology Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd. Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Energy Chemical Jinan Jiuli Biotechnology Co. , Ltd. Zhengzhou convergence chemical co., LTD