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ChemicalBook >> CAS DataBase List >> Necrostatin-7 (Nec-7)

Necrostatin-7 (Nec-7)

Necrostatin-7 (Nec-7) price.
  • $80 - $363
  • Product name: Necrostatin-7 (Nec-7)
  • CAS: 351062-08-3
  • MF: C16H10FN5OS2
  • MW: 371.41
  • EINECS:
  • MDL Number:MFCD02334728
  • Synonyms:Nec-7;Necrostatin-7 (Nec-7);5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone;Necrostatin-7;(5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one;4-Thiazolidinone, 5-[[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-;Necrostatin-7 >=98% (HPLC), powder;5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one
Price6 Properties Safety Information Description
6 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Cayman Chemical
  • Usbiological
Package
  • 5mg
  • 25mg
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0054-M005
  • Product descriptionNecrostatin-7 ≥98%(NMR)
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number6241CE
  • Product descriptionNecrostatin-7
  • Packaging5mg
  • Price$214
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10528
  • Product descriptionNecrostatin-7 ≥98%
  • Packaging5mg
  • Price$106
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10528
  • Product descriptionNecrostatin-7 ≥98%
  • Packaging25mg
  • Price$363
  • Updated2024-03-01
  • Buy
  • ManufacturerUsbiological
  • Product number045075
  • Product descriptionNecrostatin-7
  • Packaging5mg
  • Price$316
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product numberN2059-27
  • Product descriptionNecrostatin-7
  • Packaging5mg
  • Price$356
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-0054-M005 Necrostatin-7 ≥98%(NMR) 5mg $80 2021-12-16 Buy
AK Scientific 6241CE Necrostatin-7 5mg $214 2021-12-16 Buy
Cayman Chemical 10528 Necrostatin-7 ≥98% 5mg $106 2024-03-01 Buy
Cayman Chemical 10528 Necrostatin-7 ≥98% 25mg $363 2024-03-01 Buy
Usbiological 045075 Necrostatin-7 5mg $316 2021-12-16 Buy
Usbiological N2059-27 Necrostatin-7 5mg $356 2021-12-16 Buy

Properties

Boiling point :613.4±65.0 °C(Predicted)
Density :1.63±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL (with warming)
pka :11.56±0.50(Predicted)
form :powder
color :yellow to tan

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM.

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TargetMol Chemicals Inc.
Aladdin Scientific Chengdu HappySyn Pharmaceutical Technology Co., Ltd. Zhengzhou Alfachem Co., Ltd. Shanghai EFE Biological Technology Co., Ltd. Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Energy Chemical TargetMol Chemicals Inc. Suzhou Zhixin Biotechnology Co., Ltd.