O-7460

$65 - $632
Product name: O-7460
CAS: 1572051-31-0
MF: C25H48FO5P
MW: 478.618
EINECS:
MDL Number:
Synonyms:O-7460;ZLEFMXNNQCABDB-SEYXRHQNSA-N;1-((fluoro(methyl)phosphoryl)oxy)-3-isopropoxypropan-2-yl oleate;O7460,O 7460;9-Octadecenoic acid (9Z)-, 2-[(fluoromethylphosphinyl)oxy]-1-[(1-methylethoxy)methyl]ethyl ester

Price5 Properties Safety Information Description

5 prices

Selected condition：

Brand

Cayman Chemical
TRC
Usbiological

Package

500μg
1mg
5mg
500g

ManufacturerCayman Chemical
Product number14009
Product descriptionO-7460 ≥95%
Packaging500μg
Price$81
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number14009
Product descriptionO-7460 ≥95%
Packaging1mg
Price$152
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number14009
Product descriptionO-7460 ≥95%
Packaging5mg
Price$632
Updated2024-03-01
Buy

ManufacturerTRC
Product numberO003500
Product descriptionO-7460
Packaging500g
Price$65
Updated2021-12-16
Buy

ManufacturerUsbiological
Product number461164
Product descriptionO-7460
Packaging500g
Price$333
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Cayman Chemical	14009	O-7460 ≥95%	500μg	$81	2024-03-01	Buy
Cayman Chemical	14009	O-7460 ≥95%	1mg	$152	2024-03-01	Buy
Cayman Chemical	14009	O-7460 ≥95%	5mg	$632	2024-03-01	Buy
TRC	O003500	O-7460	500g	$65	2021-12-16	Buy
Usbiological	461164	O-7460	500g	$333	2021-12-16	Buy

Properties

Boiling point :536.5±50.0 °C(Predicted)
Density :0.994±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H225	Highly Flammable liquid and vapour	Flammable liquids	Category 2	Danger	P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H336	May cause drowsiness or dizziness	Specific target organ toxicity,single exposure; Narcotic effects	Category 3	Warning	P261, P271, P304+P340, P312,P403+P233, P405, P501

Precautionary statements:

P210	Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P370+P378	In case of fire: Use … for extinction.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P403+P235	Store in a well-ventilated place. Keep cool.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG; ) by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM). It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 μM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 μM). At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight.

Suppliers and manufacturers

Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Energy Chemical MedBioPharmaceutical Technology Inc

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