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ChemicalBook >> CAS DataBase List >> OM-137

OM-137

OM-137 price.
  • $99.3 - $377
  • Product name: OM-137
  • CAS: 292170-13-9
  • MF: C13H14N4O3S
  • MW: 306.34
  • EINECS:
  • MDL Number:MFCD02086738
  • Synonyms:OM-137;2-Amino-N′-(4-hydroxy-3-methoxybenzylidene)-4-methyl-1,3-thiazole-5-carbohydrazide;5-Thiazolecarboxylic acid, 2-amino-4-methyl-, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide;2-amino-N'-[(1E)-(4-hydroxy-3-methoxyphenyl)methylidene]-4-methyl-1,3-thiazole-5-carbohydrazide;OM137 >=95% (NMR)
3 prices
Selected condition:
Brand
  • American Custom Chemicals Corporation
  • Sigma-Aldrich
Package
  • 5mg
  • 25mg
  • 100MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001268
  • Product descriptionOM137 95.00%
  • Packaging100MG
  • Price$346.5
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberO8140
  • Product descriptionOM137 ≥95% (NMR)
  • Packaging5mg
  • Price$99.3
  • Updated2022-05-15
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberO8140
  • Product descriptionOM137 ≥95% (NMR)
  • Packaging25mg
  • Price$377
  • Updated2022-05-15
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation KIN0001268 OM137 95.00% 100MG $346.5 2021-12-16 Buy
Sigma-Aldrich O8140 OM137 ≥95% (NMR) 5mg $99.3 2022-05-15 Buy
Sigma-Aldrich O8140 OM137 ≥95% (NMR) 25mg $377 2022-05-15 Buy

Properties

Density :1.46±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: >10mg/mL
form :powder
pka :8.65±0.35(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

OM137 is an inhibitor of ARKs. It is an aminothiazole derivative, which functions to override the spindle checkpoint primarily through inhibition of the ARKs (mitotic kinases). OM137 is a more potent inhibitor of ARK-2 compared with ARK-1 in vitro. The compounda has some CDK1 inhibitory activity, but is likely that the major mode by which it drives mitotic exit of cells arrested in M phase via the spindle checkpoint is through its inhibitory activity against ARK-2.