OSI-027
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- $37 - $3728.1
- Product name: OSI-027
- CAS: 936890-98-1
- MF: C21H22N6O3
- MW: 406.44
- EINECS:-0
- MDL Number:MFCD20275101
- Synonyms:OSI-027;trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid;4-(4-aMino-5-(7-Methoxy-1H-indol-2-yl)-1,2-dihydroiMidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid hydrochloride;4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f] [1,2,4]Triazin-7-yl)cyclohexanecarboxylic Acid;(1r,4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[1,5-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid;ASP4786;OSI-027 trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid;trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid OSI-027
23 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2616AH
- Product descriptionOSI-027
- Packaging1mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001406
- Product descriptionOSI-027 95.00%
- Packaging5MG
- Price$497.13
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1637
- Product descriptionOSI-027
- Packaging5mg
- Price$83
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60235
- Product descriptionOSI-027 ≥98%
- Packaging10mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611257
- Product descriptionOSI-027 >99%
- Packaging100mg
- Price$1133.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611257
- Product descriptionOSI-027 >99%
- Packaging1g
- Price$3728.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17379
- Product descriptionOSI-027 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17379
- Product descriptionOSI-027 ≥98%
- Packaging5mg
- Price$134
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17379
- Product descriptionOSI-027 ≥98%
- Packaging10mg
- Price$249
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17379
- Product descriptionOSI-027 ≥98%
- Packaging50mg
- Price$670
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0257
- Product descriptionOSI-027 99.40%
- Packaging5mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0257
- Product descriptionOSI-027 99.40%
- Packaging10mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0257
- Product descriptionOSI-027 99.40%
- Packaging50mg
- Price$576
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000176
- Product descriptionOSI-027 98+%
- Packaging5mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000176
- Product descriptionOSI-027 98+%
- Packaging10mg
- Price$114
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000176
- Product descriptionOSI-027 98+%
- Packaging50mg
- Price$312
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2616AH | OSI-027 | 1mg | $88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001406 | OSI-027 95.00% | 5MG | $497.13 | 2021-12-16 | Buy |
| ApexBio Technology | B1637 | OSI-027 | 5mg | $83 | 2021-12-16 | Buy |
| Arctom | CFN60235 | OSI-027 ≥98% | 10mg | $288 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611257 | OSI-027 >99% | 100mg | $1133.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611257 | OSI-027 >99% | 1g | $3728.1 | 2021-12-16 | Buy |
| Cayman Chemical | 17379 | OSI-027 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17379 | OSI-027 ≥98% | 5mg | $134 | 2024-03-01 | Buy |
| Cayman Chemical | 17379 | OSI-027 ≥98% | 10mg | $249 | 2024-03-01 | Buy |
| Cayman Chemical | 17379 | OSI-027 ≥98% | 50mg | $670 | 2024-03-01 | Buy |
| ChemScene | CS-0257 | OSI-027 99.40% | 5mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-0257 | OSI-027 99.40% | 10mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-0257 | OSI-027 99.40% | 50mg | $576 | 2021-12-16 | Buy |
| Crysdot | CD31000176 | OSI-027 98+% | 5mg | $59 | 2021-12-16 | Buy |
| Crysdot | CD31000176 | OSI-027 98+% | 10mg | $114 | 2021-12-16 | Buy |
| Crysdot | CD31000176 | OSI-027 98+% | 50mg | $312 | 2021-12-16 | Buy |
Properties
Melting point :>149°C (subl.)
Density :1.59
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly)
pka :4.44±0.10(Predicted)
form :Solid
color :Pale Beige to Light Beige
Density :1.59
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly)
pka :4.44±0.10(Predicted)
form :Solid
color :Pale Beige to Light Beige
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin ) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of mTOR and, as a result, inhibits both mTORC1 and mTORC2 (IC50s = 22 and 65 nM, respectively). It is selective for mTOR over phosphatidylinositol 3-kinase isoforms and DNA protein kinase. OSI-027 prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 μM. OSI-027 is effective in vivo, blocking the phosphorylation of targets of mTORC1 and mTORC2 and suppressing tumor growth in several different human xenograft models.More related product prices
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