PCNA-I1
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- $68 - $1700
- Product name: PCNA-I1
- CAS: 444930-42-1
- MF: C17H14N2O2S
- MW: 310.37
- EINECS:
- MDL Number:
- Synonyms:N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide;2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide;PCNA-I1,PCNA-I-1,DNA/RNA Synthesis,inhibit,PCNAI1,Inhibitor,PCNA I1;N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide;N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide
8 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- DC Chemicals
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2656EM
- Product descriptionPcna-I1
- Packaging10mg
- Price$241
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5080
- Product descriptionPCNA-I1
- Packaging50mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number20454
- Product descriptionPCNA-I1 ≥98%
- Packaging5mg
- Price$68
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20454
- Product descriptionPCNA-I1 ≥98%
- Packaging10mg
- Price$130
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20454
- Product descriptionPCNA-I1 ≥98%
- Packaging25mg
- Price$302
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20454
- Product descriptionPCNA-I1 ≥98%
- Packaging50mg
- Price$535
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC43506
- Product descriptionPCNA-I1 >98%
- Packaging250mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC43506
- Product descriptionPCNA-I1 >98%
- Packaging1g
- Price$1700
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2656EM | Pcna-I1 | 10mg | $241 | 2021-12-16 | Buy |
| AK Scientific | SYN5080 | PCNA-I1 | 50mg | $500 | 2021-12-16 | Buy |
| Cayman Chemical | 20454 | PCNA-I1 ≥98% | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 20454 | PCNA-I1 ≥98% | 10mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 20454 | PCNA-I1 ≥98% | 25mg | $302 | 2024-03-01 | Buy |
| Cayman Chemical | 20454 | PCNA-I1 ≥98% | 50mg | $535 | 2024-03-01 | Buy |
| DC Chemicals | DC43506 | PCNA-I1 >98% | 250mg | $850 | 2021-12-16 | Buy |
| DC Chemicals | DC43506 | PCNA-I1 >98% | 1g | $1700 | 2021-12-16 | Buy |
Properties
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :A crystalline solid
pka :8.31±0.50(Predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :A crystalline solid
pka :8.31±0.50(Predicted)
color :Light yellow to yellow
Safety Information
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Description
PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 μM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 μM) over non-transformed cells (IC50s = 0.99-2 μM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.Suppliers and manufacturers
TargetMol Chemicals Inc.
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
Amadis Chemical Company Limited
Pharmacodia (Beijing) Co.,Ltd
Shanghai EFE Biological Technology Co., Ltd.
Tianjin Kailiqi Biotechnology Co., Ltd.
ShangHai Biochempartner Co.,Ltd
Shanghai Rechem science Co., Ltd.