PD04217903
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- $44 - $4183.99
- Product name: PD04217903
- CAS: 956905-27-4
- MF: C19H16N8O
- MW: 372.38
- EINECS:
- MDL Number:MFCD12407410
- Synonyms:PD04217903;2-[4-[1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl]ethanol;2-(4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-1H-pyrazol-1-yl)ethanol;2-[4-[1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl]ethanol PF 04217903;PF 04217903 2-[4-[1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl]ethanol;2-{4-[1-(6-Quinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-y l]-1H-pyrazol-1-yl}ethanol;PF-04217903;PF 04217903;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol
29 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 5mg
- 10mM(in 1mL DMSO)
- 1MG
- 10MG
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1060-M005
- Product descriptionPF-04217903 ≥95%
- Packaging5mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1060-M050
- Product descriptionPF-04217903 ≥95%
- Packaging50mg
- Price$486
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1060
- Product descriptionPF04217903
- Packaging50mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000776
- Product descriptionPD-04217903 95.00%
- Packaging10MG
- Price$4183.99
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000776
- Product descriptionPD-04217903 95.00%
- Packaging5MG
- Price$2934.86
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000776
- Product descriptionPD-04217903 95.00%
- Packaging1MG
- Price$672
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5096
- Product descriptionPF-04217903
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5096
- Product descriptionPF-04217903
- Packaging10mM(in 1mL DMSO)
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5096
- Product descriptionPF-04217903
- Packaging25mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5096
- Product descriptionPF-04217903
- Packaging100mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60403
- Product descriptionPF-04217903 ≥98%
- Packaging10mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17931
- Product descriptionPF-04217903 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17931
- Product descriptionPF-04217903 ≥98%
- Packaging5mg
- Price$118
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17931
- Product descriptionPF-04217903 ≥98%
- Packaging10mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17931
- Product descriptionPF-04217903 ≥98%
- Packaging25mg
- Price$426
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM144660
- Product description2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol 98%
- Packaging100mg
- Price$420
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1060-M005 | PF-04217903 ≥95% | 5mg | $119 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1060-M050 | PF-04217903 ≥95% | 50mg | $486 | 2021-12-16 | Buy |
| AK Scientific | SYN1060 | PF04217903 | 50mg | $470 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000776 | PD-04217903 95.00% | 10MG | $4183.99 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000776 | PD-04217903 95.00% | 5MG | $2934.86 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000776 | PD-04217903 95.00% | 1MG | $672 | 2021-12-16 | Buy |
| ApexBio Technology | A5096 | PF-04217903 | 5mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A5096 | PF-04217903 | 10mM(in 1mL DMSO) | $79 | 2021-12-16 | Buy |
| ApexBio Technology | A5096 | PF-04217903 | 25mg | $210 | 2021-12-16 | Buy |
| ApexBio Technology | A5096 | PF-04217903 | 100mg | $470 | 2021-12-16 | Buy |
| Arctom | CFN60403 | PF-04217903 ≥98% | 10mg | $208 | 2021-12-16 | Buy |
| Cayman Chemical | 17931 | PF-04217903 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17931 | PF-04217903 ≥98% | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 17931 | PF-04217903 ≥98% | 10mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 17931 | PF-04217903 ≥98% | 25mg | $426 | 2024-03-01 | Buy |
| Chemenu | CM144660 | 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol 98% | 100mg | $420 | 2021-12-16 | Buy |
Properties
Boiling point :718.1±60.0 °C(Predicted)
Density :1.53
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥18.6 mg/mL in DMSO
pka :14.31±0.10(Predicted)
form :solid
color :White to off-white
Density :1.53
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥18.6 mg/mL in DMSO
pka :14.31±0.10(Predicted)
form :solid
color :White to off-white
Safety Information
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Description
MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. PF-04217903 is a class I c-Met kinase inhibitor (Ki = 4.8 nM) that demonstrates more than 1,000-fold selectivity for c-Met compared with more than 150 kinases. It can inhibit tumor cell proliferation, survival, and migration/invasion in MET-amplified cell lines in vitro (IC50s = 12-31 nM), and shows antitumor activity in in vivo tumor models harboring either MET gene amplification or a hepatocyte growth factor/c-Met autocrine loop. PF-04217903 underwent phase I clinical trials in 2010.More related product prices
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