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ChemicalBook >> CAS DataBase List >> PD04217903

PD04217903

PD04217903 price.
  • $44 - $4183.99
  • Product name: PD04217903
  • CAS: 956905-27-4
  • MF: C19H16N8O
  • MW: 372.38
  • EINECS:
  • MDL Number:MFCD12407410
  • Synonyms:PD04217903;2-[4-[1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl]ethanol;2-(4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-1H-pyrazol-1-yl)ethanol;2-[4-[1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl]ethanol PF 04217903;PF 04217903 2-[4-[1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl]ethanol;2-{4-[1-(6-Quinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-y l]-1H-pyrazol-1-yl}ethanol;PF-04217903;PF 04217903;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol
29 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 5mg
  • 10mM(in 1mL DMSO)
  • 1MG
  • 10MG
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1060-M005
  • Product descriptionPF-04217903 ≥95%
  • Packaging5mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1060-M050
  • Product descriptionPF-04217903 ≥95%
  • Packaging50mg
  • Price$486
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1060
  • Product descriptionPF04217903
  • Packaging50mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000776
  • Product descriptionPD-04217903 95.00%
  • Packaging1MG
  • Price$672
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000776
  • Product descriptionPD-04217903 95.00%
  • Packaging5MG
  • Price$2934.86
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000776
  • Product descriptionPD-04217903 95.00%
  • Packaging10MG
  • Price$4183.99
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5096
  • Product descriptionPF-04217903
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5096
  • Product descriptionPF-04217903
  • Packaging10mM(in 1mL DMSO)
  • Price$79
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5096
  • Product descriptionPF-04217903
  • Packaging25mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5096
  • Product descriptionPF-04217903
  • Packaging100mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60403
  • Product descriptionPF-04217903 ≥98%
  • Packaging10mg
  • Price$208
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17931
  • Product descriptionPF-04217903 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17931
  • Product descriptionPF-04217903 ≥98%
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17931
  • Product descriptionPF-04217903 ≥98%
  • Packaging10mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17931
  • Product descriptionPF-04217903 ≥98%
  • Packaging25mg
  • Price$426
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM144660
  • Product description2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol 98%
  • Packaging100mg
  • Price$420
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1060-M005 PF-04217903 ≥95% 5mg $119 2021-12-16 Buy
Adipogen Life Sciences SYN-1060-M050 PF-04217903 ≥95% 50mg $486 2021-12-16 Buy
AK Scientific SYN1060 PF04217903 50mg $470 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000776 PD-04217903 95.00% 1MG $672 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000776 PD-04217903 95.00% 5MG $2934.86 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000776 PD-04217903 95.00% 10MG $4183.99 2021-12-16 Buy
ApexBio Technology A5096 PF-04217903 5mg $70 2021-12-16 Buy
ApexBio Technology A5096 PF-04217903 10mM(in 1mL DMSO) $79 2021-12-16 Buy
ApexBio Technology A5096 PF-04217903 25mg $210 2021-12-16 Buy
ApexBio Technology A5096 PF-04217903 100mg $470 2021-12-16 Buy
Arctom CFN60403 PF-04217903 ≥98% 10mg $208 2021-12-16 Buy
Cayman Chemical 17931 PF-04217903 ≥98% 1mg $44 2024-03-01 Buy
Cayman Chemical 17931 PF-04217903 ≥98% 5mg $118 2024-03-01 Buy
Cayman Chemical 17931 PF-04217903 ≥98% 10mg $193 2024-03-01 Buy
Cayman Chemical 17931 PF-04217903 ≥98% 25mg $426 2024-03-01 Buy
Chemenu CM144660 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol 98% 100mg $420 2021-12-16 Buy

Properties

Boiling point :718.1±60.0 °C(Predicted)
Density :1.53
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥18.6 mg/mL in DMSO
pka :14.31±0.10(Predicted)
form :solid
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. PF-04217903 is a class I c-Met kinase inhibitor (Ki = 4.8 nM) that demonstrates more than 1,000-fold selectivity for c-Met compared with more than 150 kinases. It can inhibit tumor cell proliferation, survival, and migration/invasion in MET-amplified cell lines in vitro (IC50s = 12-31 nM), and shows antitumor activity in in vivo tumor models harboring either MET gene amplification or a hepatocyte growth factor/c-Met autocrine loop. PF-04217903 underwent phase I clinical trials in 2010.

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