PF-05274857 HCl
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- $25 - $1025
- Product name: PF-05274857 HCl
- CAS: 1613439-62-5
- MF: C20H26Cl2N4O3S
- MW: 473.41
- EINECS:
- MDL Number:MFCD24387542
- Synonyms:PF-05274857 HCl;1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one:hydrochloride;1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride;PF-05274857 hydrochloride ≥95%;PF 5274857 hydiochloride;1-(4-(5'-Chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one hydrochloride
9 prices
Selected condition：
Brand
- Cayman Chemical
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 2.5mg
- 5mg
- 10mg
- 25mg
- ManufacturerCayman Chemical
- Product number15022
- Product descriptionPF-05274857 (hydrochloride) ≥98%
- Packaging1mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15022
- Product descriptionPF-05274857 (hydrochloride) ≥98%
- Packaging5mg
- Price$81
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15022
- Product descriptionPF-05274857 (hydrochloride) ≥98%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15022
- Product descriptionPF-05274857 (hydrochloride) ≥98%
- Packaging25mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number60981
- Product descriptionPF-05274857HCl
- Packaging2.5mg
- Price$625
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number60981
- Product descriptionPF-05274857HCl
- Packaging5mg
- Price$735
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number60981
- Product descriptionPF-05274857HCl
- Packaging25mg
- Price$1025
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberP227585
- Product descriptionPF-05274857Hydrochloride
- Packaging2.5mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberP227585
- Product descriptionPF-05274857Hydrochloride
- Packaging10mg
- Price$385
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 15022 | PF-05274857 (hydrochloride) ≥98% | 1mg | $25 | 2021-12-16 | Buy |
| Cayman Chemical | 15022 | PF-05274857 (hydrochloride) ≥98% | 5mg | $81 | 2021-12-16 | Buy |
| Cayman Chemical | 15022 | PF-05274857 (hydrochloride) ≥98% | 10mg | $150 | 2021-12-16 | Buy |
| Cayman Chemical | 15022 | PF-05274857 (hydrochloride) ≥98% | 25mg | $313 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 60981 | PF-05274857HCl | 2.5mg | $625 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 60981 | PF-05274857HCl | 5mg | $735 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 60981 | PF-05274857HCl | 25mg | $1025 | 2021-12-16 | Buy |
| TRC | P227585 | PF-05274857Hydrochloride | 2.5mg | $130 | 2021-12-16 | Buy |
| TRC | P227585 | PF-05274857Hydrochloride | 10mg | $385 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO (Slightly, Heated), Water (Slightly)
form :Solid
color :Light Yellow
solubility :DMSO (Slightly, Heated), Water (Slightly)
form :Solid
color :Light Yellow
Safety Information
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Description
Sonic hedgehog (Shh) signaling is initiated by binding of the ligand, Shh, to the receptor Patched 1, which relieves suppression by the associated receptor Smoothened (Smo). PF-05274857 is an antagonist which binds Smo (Ki = 4.6 nM), blocking Gli1 transcription in cells stimulated with Shh (IC50 = 2.7 nM). When administered orally, it distributes through plasma to skin and tumor and remains metabolically stable. PF-05274857 also penetrates the blood-brain barrier and inhibits Smo activity in the brain.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Hangzhou MolCore BioPharmatech Co.,Ltd.
Chemtour Biotech Co., Ltd
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
Amadis Chemical Company Limited
Pharmacodia (Beijing) Co.,Ltd
Shanghai EFE Biological Technology Co., Ltd.
ShangHai Biochempartner Co.,Ltd
Shanghai Chaolan Chemical Technology Center