PHA 767491 HYDROCHLORIDE
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- $35 - $1200
- Product name: PHA 767491 HYDROCHLORIDE
- CAS: 845714-00-3
- MF: C12H11N3O
- MW: 213.24
- EINECS:
- MDL Number:MFCD11870790
- Synonyms:PHA-767491;CAY10572;1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one;PHA 767491 HYDROCHLORIDE;1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-onehydrochloride;2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one;2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one;PHA-767491HCL
20 prices
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Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Tocris
- TRC
- Usbiological
Package
- 10
- 1MG
- 5MG
- 50
- 10MG
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000310
- Product descriptionPHA-767491 95.00%
- Packaging1MG
- Price$593.04
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000310
- Product descriptionPHA-767491 95.00%
- Packaging5MG
- Price$795.33
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000310
- Product descriptionPHA-767491 95.00%
- Packaging10MG
- Price$924.12
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3721
- Product descriptionPHA-767491
- Packaging50mg
- Price$259
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2690
- Product descriptionPHA-767491 99%
- Packaging10mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2690
- Product descriptionPHA-767491 99%
- Packaging50mg
- Price$368.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18218
- Product descriptionPHA-767491 ≥98%
- Packaging5mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18218
- Product descriptionPHA-767491 ≥98%
- Packaging10mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18218
- Product descriptionPHA-767491 ≥98%
- Packaging25mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18218
- Product descriptionPHA-767491 ≥98%
- Packaging50mg
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000647
- Product descriptionPHA-767491(CAY10572) 98+%
- Packaging10mg
- Price$46
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000647
- Product descriptionPHA-767491(CAY10572) 98+%
- Packaging50mg
- Price$191
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8025
- Product descriptionCAY10572(PHA-767491) >98%
- Packaging100mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8025
- Product descriptionCAY10572(PHA-767491) >98%
- Packaging250mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8025
- Product descriptionCAY10572(PHA-767491) >98%
- Packaging1g
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number52704
- Product descriptionPHA767491
- Packaging50mg
- Price$860
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | KIN0000310 | PHA-767491 95.00% | 1MG | $593.04 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000310 | PHA-767491 95.00% | 5MG | $795.33 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000310 | PHA-767491 95.00% | 10MG | $924.12 | 2021-12-16 | Buy |
| ApexBio Technology | A3721 | PHA-767491 | 50mg | $259 | 2021-12-16 | Buy |
| Axon Medchem | Axon2690 | PHA-767491 99% | 10mg | $104.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2690 | PHA-767491 99% | 50mg | $368.5 | 2021-12-16 | Buy |
| Cayman Chemical | 18218 | PHA-767491 ≥98% | 5mg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 18218 | PHA-767491 ≥98% | 10mg | $60 | 2021-12-16 | Buy |
| Cayman Chemical | 18218 | PHA-767491 ≥98% | 25mg | $140 | 2021-12-16 | Buy |
| Cayman Chemical | 18218 | PHA-767491 ≥98% | 50mg | $245 | 2021-12-16 | Buy |
| Crysdot | CD31000647 | PHA-767491(CAY10572) 98+% | 10mg | $46 | 2021-12-16 | Buy |
| Crysdot | CD31000647 | PHA-767491(CAY10572) 98+% | 50mg | $191 | 2021-12-16 | Buy |
| DC Chemicals | DC8025 | CAY10572(PHA-767491) >98% | 100mg | $300 | 2021-12-16 | Buy |
| DC Chemicals | DC8025 | CAY10572(PHA-767491) >98% | 250mg | $600 | 2021-12-16 | Buy |
| DC Chemicals | DC8025 | CAY10572(PHA-767491) >98% | 1g | $1200 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 52704 | PHA767491 | 50mg | $860 | 2021-12-16 | Buy |
Properties
Density :1.287
storage temp. :Desiccate at RT
solubility :insoluble in H2O; insoluble in EtOH; ≥10.65 mg/mL in DMSO
form :solid
Stability :Hygroscopic
CAS DataBase Reference :845714-00-3
storage temp. :Desiccate at RT
solubility :insoluble in H2O; insoluble in EtOH; ≥10.65 mg/mL in DMSO
form :solid
Stability :Hygroscopic
CAS DataBase Reference :845714-00-3
Safety Information
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Description
Cdc7 kinase is a key regulator of the S-phase of the cell cycle. It is known to promote the activity of DNA replication origins in eukaryotic organisms. Inhibition of Cdc7 kinase causes blockade of DNA synthesis in human cell lines. Tumor cells are then funneled into the apoptotic pathway in a p53-independent manner. Pharmacological inhibition of Cdc7 kinase can be an effective strategy for the development of oncologic therapeutics useful for treatment of cancers. PHA-767491 is a potent inhibitor of Cdc7 kinase with an IC50 value of 10 nM in the presence of 1.5 μM ATP. At 10 μM, PHA-767491 induces apoptotic cell death in multiple cancer cell types. PHA-767491 also inhibits Cdk9, a kinase involved in the phosphorylation of RNA polymerase II and in transcriptional regulation of gene expression, with an IC50 value of 34 nM.Related product price
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