PLX647
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- $60 - $850
- Product name: PLX647
- CAS: 873786-09-5
- MF: C21H17F3N4
- MW: 382.38
- EINECS:
- MDL Number:MFCD28100808
- Synonyms:PLX647;PLC647;5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine;[5-[(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-yl](4-trifluoromethylbenzyl)amine;2-Pyridinamine, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-;PLX 647;PLX-647;CS-1696;5-({1H-pyrrolo[2,3-b]pyridin-3-yl}methyl)-N-{[4-(trifluoromethyl)phenyl]methyl}pyridin-2-amine
18 prices
Selected condition：
Brand
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 5mg
- 25mg
- 100mg
- 250mg
- 10mg
- 50mg
- 10mM(in 1mL DMSO)
- ManufacturerApexBio Technology
- Product numberB5816
- Product descriptionPLX647
- Packaging10mM(in 1mL DMSO)
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5816
- Product descriptionPLX647
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5816
- Product descriptionPLX647
- Packaging50mg
- Price$580
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18012
- Product descriptionPLX647 ≥95%
- Packaging5mg
- Price$97
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18012
- Product descriptionPLX647 ≥95%
- Packaging10mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18012
- Product descriptionPLX647 ≥95%
- Packaging25mg
- Price$433
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18012
- Product descriptionPLX647 ≥95%
- Packaging50mg
- Price$768
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM149779
- Product description5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-(4-(trifluoromethyl)benzyl)pyridin-2-amine 95%+
- Packaging50mg
- Price$386
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3984
- Product descriptionPLX647 99.07%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3984
- Product descriptionPLX647 99.07%
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3984
- Product descriptionPLX647 99.07%
- Packaging50mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3984
- Product descriptionPLX647 99.07%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000464
- Product descriptionPLX647 98+%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000464
- Product descriptionPLX647 98+%
- Packaging10mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000464
- Product descriptionPLX647 98+%
- Packaging50mg
- Price$413
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8107
- Product descriptionPLX647 >98%
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ApexBio Technology | B5816 | PLX647 | 10mM(in 1mL DMSO) | $90 | 2021-12-16 | Buy |
| ApexBio Technology | B5816 | PLX647 | 10mg | $140 | 2021-12-16 | Buy |
| ApexBio Technology | B5816 | PLX647 | 50mg | $580 | 2021-12-16 | Buy |
| Cayman Chemical | 18012 | PLX647 ≥95% | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 18012 | PLX647 ≥95% | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 18012 | PLX647 ≥95% | 25mg | $433 | 2024-03-01 | Buy |
| Cayman Chemical | 18012 | PLX647 ≥95% | 50mg | $768 | 2024-03-01 | Buy |
| Chemenu | CM149779 | 5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-(4-(trifluoromethyl)benzyl)pyridin-2-amine 95%+ | 50mg | $386 | 2021-12-16 | Buy |
| ChemScene | CS-3984 | PLX647 99.07% | 5mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-3984 | PLX647 99.07% | 10mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-3984 | PLX647 99.07% | 50mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-3984 | PLX647 99.07% | 100mg | $450 | 2021-12-16 | Buy |
| Crysdot | CD31000464 | PLX647 98+% | 5mg | $60 | 2021-12-16 | Buy |
| Crysdot | CD31000464 | PLX647 98+% | 10mg | $105 | 2021-12-16 | Buy |
| Crysdot | CD31000464 | PLX647 98+% | 50mg | $413 | 2021-12-16 | Buy |
| DC Chemicals | DC8107 | PLX647 >98% | 100mg | $500 | 2021-12-16 | Buy |
Properties
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :13.73±0.40(Predicted)
color :white to beige
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :13.73±0.40(Predicted)
color :white to beige
Safety Information
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Description
PLX647 is a dual inhibitor of the receptor tyrosine kinases FMS and KIT (IC50s = 28 and 16 nM, respectively). It is selective for FMS and KIT but does inhibit FLT3 and KDR (IC50s = 91 and 130 nM, respectively) in a panel of 400 kinases at a concentration of 1 μM. PLX647 inhibits proliferation of Ba/F3 cells expressing constitutively active FMS or KIT (IC50s = 92 and 180 nM, respectively) as well as ligand-dependent growth of M-NFS-60 and M-07e cells that express endogenous FMS and KIT, respectively (IC50s = 380 and 230 nM, respectively). It has no effect on HEK293T or HepG2 cells that lack FMS and KIT (IC50 = >50 μM) or Ba/F3 cells overexpressing KDR (IC50 = >5 μM). PLX647 also inhibits differentiation of human osteoclast precursor cells (IC50 = 170 nM). In vivo, PLX647 (40 mg/kg) reduces TNF-α and IL-6 release in a rat model of LPS-induced cytokine release. It reduces mast cell degranulation in a mouse model of passive cutaneous anaphylaxis (PCA) and inhibits bone destruction and delays disease progression in a mouse model of collagen-induced arthritis (CIA). PLX647 also reverses bone osteolysis and allodynia in a syngeneic rat model of cancer-induced bone pain.Related product price
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