Phortress
|
- $97 - $1511
- Product name: Phortress
- CAS: 328087-38-3
- MF: C20H25Cl2FN4OS
- MW: 459.4081032
- EINECS:
- MDL Number:
- Synonyms:Phortress;Phortress (hydrochloride);(2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride
8 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- Tocris
- Usbiological
Package
- 10mg
- 10
- 5mg
- 50mg
- ManufacturerAK Scientific
- Product number3123CR
- Product descriptionPhortress
- Packaging10mg
- Price$302
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8614
- Product descriptionPhortress
- Packaging10mg
- Price$377
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8614
- Product descriptionPhortress
- Packaging50mg
- Price$1511
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15342
- Product descriptionPhortress ≥98%
- Packaging5mg
- Price$97
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15342
- Product descriptionPhortress ≥98%
- Packaging10mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15342
- Product descriptionPhortress ≥98%
- Packaging50mg
- Price$768
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number4995
- Product descriptionPhortress ≥98%(HPLC)
- Packaging10
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number256238
- Product descriptionPhortress
- Packaging10mg
- Price$502
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3123CR | Phortress | 10mg | $302 | 2021-12-16 | Buy |
| ApexBio Technology | A8614 | Phortress | 10mg | $377 | 2021-12-16 | Buy |
| ApexBio Technology | A8614 | Phortress | 50mg | $1511 | 2021-12-16 | Buy |
| Cayman Chemical | 15342 | Phortress ≥98% | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 15342 | Phortress ≥98% | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 15342 | Phortress ≥98% | 50mg | $768 | 2024-03-01 | Buy |
| Tocris | 4995 | Phortress ≥98%(HPLC) | 10 | $200 | 2021-12-16 | Buy |
| Usbiological | 256238 | Phortress | 10mg | $502 | 2021-12-16 | Buy |
Properties
solubility :Soluble to 100 mM in DMSO
form :Powder
form :Powder
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. Phortress is a lysyl amide prodrug of the benzothiazole 5-fluoro 203 , a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1, which leads to the formation of DNA adducts and cell cycle arrest. Phortress rapidly reverts to 5-fluoro 203 in carcinoma cell lines, resulting in significant growth inhibition at nanomolar concentrations. At 20 mg/kg, phortress can suppress the growth of breast and ovarian xenografts in vivo.Suppliers and manufacturers
TargetMol Chemicals Inc.
Aladdin Scientific
EMMX Biotechnology LLC
BOC Sciences
Changzhou Chenhong Biotechnology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
MedBioPharmaceutical Technology Inc
TargetMol Chemicals Inc.
Shanghai Yifei Biotechnology Co. , Ltd.
Shanghai Haozhu Pharmaceutical Technology Co. , Ltd.