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ChemicalBook >> CAS DataBase List >> RPI-1

RPI-1

RPI-1 price.
  • $32 - $2200
  • Product name: RPI-1
  • CAS: 269730-03-2
  • MF: C17H15NO4
  • MW: 297.31
  • EINECS:
  • MDL Number:MFCD03852474
  • Synonyms:RPI-1;RPI-1 (e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide;1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-H-indol-2-one;2H-Indol-2-one,1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-;3-[(4-hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one;CS-2266;RPI1;RPI 1;1,3-Dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-1H-indol-2-one
19 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Chem-Impex
  • Crysdot
  • DC Chemicals
  • TCI Chemical
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25MG
  • 50MG
  • 250mg
  • 500MG
  • 1g
  • 5ML
  • ManufacturerAK Scientific
  • Product number2719CG
  • Product descriptionCID1749978
  • Packaging5mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001260
  • Product descriptionRPI 1 95.00%
  • Packaging25MG
  • Price$942.31
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001260
  • Product descriptionRPI 1 95.00%
  • Packaging5ML
  • Price$980.02
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001260
  • Product descriptionRPI 1 95.00%
  • Packaging500MG
  • Price$1435
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4239
  • Product descriptionRPI 1
  • Packaging5mg
  • Price$123
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4239
  • Product descriptionRPI 1
  • Packaging10mg
  • Price$227
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4239
  • Product descriptionRPI 1
  • Packaging25mg
  • Price$520
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number20384
  • Product descriptionRPI 1 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20384
  • Product descriptionRPI 1 ≥98%
  • Packaging5mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20384
  • Product descriptionRPI 1 ≥98%
  • Packaging10mg
  • Price$199
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20384
  • Product descriptionRPI 1 ≥98%
  • Packaging25mg
  • Price$456
  • Updated2024-03-01
  • Buy
  • ManufacturerChem-Impex
  • Product number42184
  • Product descriptionRPI1,95%(HPLC) 95%(HPLC)
  • Packaging10MG
  • Price$239.68
  • Updated2021-12-16
  • Buy
  • ManufacturerChem-Impex
  • Product number42184
  • Product descriptionRPI1,≥95%(HPLC) ≥95%(HPLC)
  • Packaging50MG
  • Price$837.49
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11155710
  • Product descriptionRPI 1 97%
  • Packaging1g
  • Price$895
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7986
  • Product descriptionRPI 1 >98%
  • Packaging250mg
  • Price$1210
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7986
  • Product descriptionRPI 1 >98%
  • Packaging1g
  • Price$2200
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2719CG CID1749978 5mg $218 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001260 RPI 1 95.00% 25MG $942.31 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001260 RPI 1 95.00% 5ML $980.02 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001260 RPI 1 95.00% 500MG $1435 2021-12-16 Buy
ApexBio Technology C4239 RPI 1 5mg $123 2021-12-16 Buy
ApexBio Technology C4239 RPI 1 10mg $227 2021-12-16 Buy
ApexBio Technology C4239 RPI 1 25mg $520 2021-12-16 Buy
Cayman Chemical 20384 RPI 1 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 20384 RPI 1 ≥98% 5mg $109 2024-03-01 Buy
Cayman Chemical 20384 RPI 1 ≥98% 10mg $199 2024-03-01 Buy
Cayman Chemical 20384 RPI 1 ≥98% 25mg $456 2024-03-01 Buy
Chem-Impex 42184 RPI1,95%(HPLC) 95%(HPLC) 10MG $239.68 2021-12-16 Buy
Chem-Impex 42184 RPI1,≥95%(HPLC) ≥95%(HPLC) 50MG $837.49 2021-12-16 Buy
Crysdot CD11155710 RPI 1 97% 1g $895 2021-12-16 Buy
DC Chemicals DC7986 RPI 1 >98% 250mg $1210 2021-12-16 Buy
DC Chemicals DC7986 RPI 1 >98% 1g $2200 2021-12-16 Buy

Properties

storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >20mg/mL
form :powder to crystal
color :orange

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

RPI-1 is a cell-permeable, indolinone-based ATP-competitive tyrosine kinase inhibitor that is known to target Ret, EGFR, and Met. Increased tumorigenicity, motility, and invasiveness have been described as biological consequences of HGF/Met deregulation in tumor cells, thus RPI-1 treatment of H460 cells resulted in a strong reduction of both colony number and size. The compound is also active at mouse NSCLC H460 xenograft tumor and metastasis model. Mechanistically RPI-1 inhibits Met phosphorylation at Tyr1234/Tyr1235, known to activate the intrinsic kinase activity. Selectively reverts the morphologic phenotype of ret oncogene- (PTC1 & MEN2A), but not H-Ras-, and transformed NIH3T3 in a reversible manner. RPI-1 effectively inhibits the autophosphorylation of PTC1, MEN2A, and Met against Met in N592 in cancer cells, and concomitant receptor down-regulation has also been reported to occur in NIH3T3MEN2A and in small cell lung carcinoma cell line N592.