(S)-3'-amino Blebbistatin

$121 - $1302
Product name: (S)-3'-amino Blebbistatin
CAS: 2097141-18-7
MF: C18H17N3O2
MW: 307.35
EINECS:
MDL Number:
Synonyms:-amino Blebbistatin;4H-Pyrrolo[2,3-b]quinolin-4-one, 1-(3-aminophenyl)-1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-, (3aS)-;(S)-3'-amino Blebbistatin;(3aS)-1-(3-aminophenyl)-1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-4H-pyrrolo[2,3-b]quinolin-4-one;(S)-3'-amino Blebbistatin

Price4 Properties Safety Information Description

4 prices

Selected condition：

Brand

AK Scientific
Cayman Chemical

Package

500μg
1mg
5mg

ManufacturerAK Scientific
Product number4795EL
Product description(3As)-1-(3-aminophenyl)-3a-hydroxy-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
Packaging5mg
Price$1302
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number24170
Product description(S)-3'-amino Blebbistatin ≥95%
Packaging500μg
Price$121
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number24170
Product description(S)-3'-amino Blebbistatin ≥95%
Packaging1mg
Price$230
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number24170
Product description(S)-3'-amino Blebbistatin ≥95%
Packaging5mg
Price$1082
Updated2024-03-01
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	4795EL	(3As)-1-(3-aminophenyl)-3a-hydroxy-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one	5mg	$1302	2021-12-16	Buy
Cayman Chemical	24170	(S)-3'-amino Blebbistatin ≥95%	500μg	$121	2024-03-01	Buy
Cayman Chemical	24170	(S)-3'-amino Blebbistatin ≥95%	1mg	$230	2024-03-01	Buy
Cayman Chemical	24170	(S)-3'-amino Blebbistatin ≥95%	5mg	$1082	2024-03-01	Buy

Properties

Boiling point :571.3±60.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 12.5 mg/ml
form :A crystalline solid
pka :11.07±0.20(Predicted)

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

(S)-3’-amino Blebbistatin is a more stable and less phototoxic form of (–)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.^1,2 (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC₅₀ = 80 μM).³ Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.^4,5 The addition of a 3’-amino group decreases the inherent fluorescence while retaining the activity of (–)-blebbistatin.⁶ (S)-3'-amino Blebbistatin has the same stereochemistry as the active (–)-blebbistatin enantiomer.

Suppliers and manufacturers

Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Shanghai Universal Biotech Co.,Ltd Shanghai Yiyan Biotechnology Co. , Ltd. Shanghai Yifei Biotechnology Co. , Ltd. TargetMol Chemicals Inc.

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