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ChemicalBook >> (S,R,S)-AHPC-PEG4-ALKYNE

(S,R,S)-AHPC-PEG4-ALKYNE

(S,R,S)-AHPC-PEG4-ALKYNE price.
  • $243.6 - $648
  • Product name: (S,R,S)-AHPC-PEG4-ALKYNE
  • CAS: 2267282-21-1
  • MF:
  • MW: 0
  • EINECS:
  • MDL Number:
  • Synonyms:(S,R,S)-AHPC-PEG4-ALKYNE;(2S,4R)-1-[(2S)-3,3-dimethyl-2-(4,7,10,13-tetraoxahexadec-15-ynamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
2 prices
Selected condition:
Brand
  • Iris Biotech GmbH
  • Sigma-Aldrich
Package
  • 50mg
  • ManufacturerIris Biotech GmbH
  • Product numberPTC1490
  • Product description(S,R,S)-AHPC-PEG4-Alkyne
  • Packaging50mg
  • Price$648
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number901851
  • Product description(S,R,S)-AHPC-PEG4-Alkyne
  • Packaging50mg
  • Price$243.6
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Iris Biotech GmbH PTC1490 (S,R,S)-AHPC-PEG4-Alkyne 50mg $648 2021-12-16 Buy
Sigma-Aldrich 901851 (S,R,S)-AHPC-PEG4-Alkyne 50mg $243.6 2024-03-01 Buy

Properties

storage temp. :2-8°C

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.