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ChemicalBook >> CAS DataBase List >> S63845

S63845

S63845 price.
  • $86 - $1800
  • Product name: S63845
  • CAS: 1799633-27-4
  • MF: C39H37ClF4N6O6S
  • MW: 829.26
  • EINECS:-0
  • MDL Number:MFCD31382374
  • Synonyms:S63845;(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;(2R)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-, (αR)-;S 63845;S-63845;CS-2477;CS-2485;S63845 TFA
Price15 Properties Safety Information Description
15 prices
Selected condition：
Brand
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • DC Chemicals
Package
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAmbeed
  • Product numberA126292
  • Product descriptionS63845 98+%
  • Packaging1mg
  • Price$101
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126292
  • Product descriptionS63845 98+%
  • Packaging5mg
  • Price$199
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126292
  • Product descriptionS63845 98+%
  • Packaging10mg
  • Price$338
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126292
  • Product descriptionS63845 98+%
  • Packaging25mg
  • Price$606
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126292
  • Product descriptionS63845 98+%
  • Packaging50mg
  • Price$879
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126292
  • Product descriptionS63845 98+%
  • Packaging100mg
  • Price$1551
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8737
  • Product descriptionS63845
  • Packaging1mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8737
  • Product descriptionS63845
  • Packaging5mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8737
  • Product descriptionS63845
  • Packaging10mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8737
  • Product descriptionS63845
  • Packaging25mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21131
  • Product descriptionS63845 ≥98%
  • Packaging500μg
  • Price$86
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21131
  • Product descriptionS63845 ≥98%
  • Packaging1mg
  • Price$104
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21131
  • Product descriptionS63845 ≥98%
  • Packaging5mg
  • Price$212
  • Updated2024-03-01
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10137
  • Product descriptionS63845 >98%
  • Packaging25mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10137
  • Product descriptionS63845 >98%
  • Packaging100mg
  • Price$1800
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A126292 S63845 98+% 1mg $101 2021-12-16 Buy
Ambeed A126292 S63845 98+% 5mg $199 2021-12-16 Buy
Ambeed A126292 S63845 98+% 10mg $338 2021-12-16 Buy
Ambeed A126292 S63845 98+% 25mg $606 2021-12-16 Buy
Ambeed A126292 S63845 98+% 50mg $879 2021-12-16 Buy
Ambeed A126292 S63845 98+% 100mg $1551 2021-12-16 Buy
ApexBio Technology A8737 S63845 1mg $90 2021-12-16 Buy
ApexBio Technology A8737 S63845 5mg $300 2021-12-16 Buy
ApexBio Technology A8737 S63845 10mg $500 2021-12-16 Buy
ApexBio Technology A8737 S63845 25mg $1000 2021-12-16 Buy
Cayman Chemical 21131 S63845 ≥98% 500μg $86 2024-03-01 Buy
Cayman Chemical 21131 S63845 ≥98% 1mg $104 2024-03-01 Buy
Cayman Chemical 21131 S63845 ≥98% 5mg $212 2024-03-01 Buy
DC Chemicals DC10137 S63845 >98% 25mg $650 2021-12-16 Buy
DC Chemicals DC10137 S63845 >98% 100mg $1800 2021-12-16 Buy

Properties

Boiling point :852.6±65.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :4°C, protect from light, stored under nitrogen
solubility :insoluble in H2O; ≥20 mg/mL in MeOH; ≥41.45 mg/mL in DMSO
form :A crystalline solid
pka :2.54±0.11(Predicted)
color :White to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

S63845 is an inhibitor of myeloid cell leukemia 1 (Mcl-1; Ki = 0.19 nM), a pro-survival protein that is overexpressed in many cancers. It induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = <0.1-282 nM) via mitochondrial apoptosis. S63845 acts synergistically with trametinib , lapatinib , PLX4032 , and erlotinib to reduce proliferation of SK-MEL-2, BT474, A2058, and PC9 cells, respectively. S63845 (6.25-25 mg/kg) reduces tumor volume in an MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner.

Suppliers and manufacturers

career henan chemical co
S63845;
$1.00 /1KG
S63845; CAS:1799633-27-4
ATK CHEMICAL COMPANY LIMITED
Biochempartner
CONIER CHEM AND PHARMA LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Chemia Biotechnology（Shanghai） Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
CR Corporation Lomited
InvivoChem
TargetMol Chemicals Inc.