SB218078
- $140 - $1700
- Product name: SB218078
- CAS: 135897-06-2
- MF: C24H15N3O3
- MW: 393.39
- EINECS:
- MDL Number:MFCD27991263
- Synonyms:9,10,11,12-Tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione;SB218078 ?SB-218078;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione, 9,10,11,12-tetrahydro-;5,6,7,8-Tetrahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-13,15(14H)-dione
11 prices
Selected condition:
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1MG
- 2.5mg
- 5mg
- 250mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000224
- Product descriptionSB-218078 95.00%
- Packaging1MG
- Price$648.83
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3012
- Product descriptionSB218078
- Packaging1mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13335
- Product descriptionSB 218078 ≥98%
- Packaging1mg
- Price$141
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 ≥98.0%
- Packaging1mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 ≥98.0%
- Packaging5mg
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN21202
- Product descriptionSB218078
- Packaging1mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN21202
- Product descriptionSB218078
- Packaging5mg
- Price$353
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9924
- Product descriptionSB218078 >98%
- Packaging250mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9924
- Product descriptionSB218078 >98%
- Packaging1g
- Price$1700
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number559402
- Product descriptionSB 218078 - CAS 135897-06-2 - Calbiochem
- Packaging1mg
- Price$223
- Updated2023-01-07
- Buy
- ManufacturerTRC
- Product numberS155068
- Product descriptionSB218078
- Packaging2.5mg
- Price$160
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
American Custom Chemicals Corporation | KIN0000224 | SB-218078 95.00% | 1MG | $648.83 | 2021-12-16 | Buy |
ApexBio Technology | C3012 | SB218078 | 1mg | $160 | 2021-12-16 | Buy |
Cayman Chemical | 13335 | SB 218078 ≥98% | 1mg | $141 | 2024-03-01 | Buy |
ChemScene | CS-0028421 | SB-218078 ≥98.0% | 1mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-0028421 | SB-218078 ≥98.0% | 5mg | $380 | 2021-12-16 | Buy |
CSNpharm | CSN21202 | SB218078 | 1mg | $140 | 2021-12-16 | Buy |
CSNpharm | CSN21202 | SB218078 | 5mg | $353 | 2021-12-16 | Buy |
DC Chemicals | DC9924 | SB218078 >98% | 250mg | $850 | 2021-12-16 | Buy |
DC Chemicals | DC9924 | SB218078 >98% | 1g | $1700 | 2021-12-16 | Buy |
Sigma-Aldrich | 559402 | SB 218078 - CAS 135897-06-2 - Calbiochem | 1mg | $223 | 2023-01-07 | Buy |
TRC | S155068 | SB218078 | 2.5mg | $160 | 2021-12-16 | Buy |
Properties
Melting point :>340 °C
Density :1.80±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
form :crystalline solid
pka :9.75±0.20(Predicted)
color :Light yellow to yellow
Density :1.80±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
form :crystalline solid
pka :9.75±0.20(Predicted)
color :Light yellow to yellow
Safety Information
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Description
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 μM. SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan . In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.More related product prices
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