SCH 529074
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- $32 - $710
- Product name: SCH 529074
- CAS: 922150-11-6
- MF: C31H36Cl2N6
- MW: 563.56
- EINECS:
- MDL Number:MFCD27937757
- Synonyms:SCH 529074;N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine;1,3-Propanediamine, N3-[2-[[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-;N1-(2-((4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine
8 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Tocris
- TRC
Package
- 10
- 5mg
- 1mg
- 50
- 10mg
- 25mg
- ManufacturerAK Scientific
- Product number2075CT
- Product descriptionN-[2-[[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]quinazolin-4-yl]-N',N'-dimethylpropane-1,3-diamine
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21552
- Product descriptionSCH 529074 ≥98%
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21552
- Product descriptionSCH 529074 ≥98%
- Packaging10mg
- Price$230
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21552
- Product descriptionSCH 529074 ≥98%
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21552
- Product descriptionSCH 529074 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number4240
- Product descriptionSCH529074 ≥98%(HPLC)
- Packaging10
- Price$172
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4240
- Product descriptionSCH529074 ≥98%(HPLC)
- Packaging50
- Price$710
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberS200048
- Product descriptionSCH529074
- Packaging10mg
- Price$205
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2075CT | N-[2-[[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]quinazolin-4-yl]-N',N'-dimethylpropane-1,3-diamine | 1mg | $133 | 2021-12-16 | Buy |
| Cayman Chemical | 21552 | SCH 529074 ≥98% | 25mg | $533 | 2024-03-01 | Buy |
| Cayman Chemical | 21552 | SCH 529074 ≥98% | 10mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 21552 | SCH 529074 ≥98% | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 21552 | SCH 529074 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Tocris | 4240 | SCH529074 ≥98%(HPLC) | 10 | $172 | 2021-12-16 | Buy |
| Tocris | 4240 | SCH529074 ≥98%(HPLC) | 50 | $710 | 2021-12-16 | Buy |
| TRC | S200048 | SCH529074 | 10mg | $205 | 2021-12-16 | Buy |
Properties
Boiling point :640.3±55.0 °C(Predicted)
Density :1.262±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml
form :A crystalline solid
pka :9.44±0.28(Predicted)
color :Off-white to light yellow
Density :1.262±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml
form :A crystalline solid
pka :9.44±0.28(Predicted)
color :Off-white to light yellow
Safety Information
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Description
SCH 529074 is a small molecule activator of p53, a tumor suppressor that is mutated or non-functional in 50% of human tumors. SCH 529074 restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift assay with Kd values of 0.6740 and 0.4313, respectively. It also stimulates DNA binding activity and prevents human double minute-2 (Hdm-2) ubiquitination of wild-type p53 in vitro. SCH 29074 reduces proliferation of tumor cell lines with mutant and wild-type p53 (EC50s = 400-3,700 nM), with the p53 mutant cell lines being the most sensitive. In vivo, SCH 529074 reduces tumor growth in a DLD-1 human colorectal cancer xenograft model in mice in a dose-dependent manner.Suppliers and manufacturers
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Shanghai EFE Biological Technology Co., Ltd.
Shanghai Chaolan Chemical Technology Center
Shanghai Yu Ben Biotechnology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.