SIS3
|
- $68 - $1114
- Product name: SIS3
- CAS: 521984-48-5
- MF: C28H27N3O3HCl
- MW: 0
- EINECS:
- MDL Number:MFCD09265258
- Synonyms:SIS3;(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride;2-Propen-1-one,1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-,hydrochloride (1:1), (2E)-;SIS3 hydrochloride;SIS3 HCl;1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride;Caneritinib(CI-1033);SIS 3 HCL;SIS-3 HCL
14 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10
- 1mg
- 50
- 2mg
- 5MG
- 10mg
- 25mg
- 100mg
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004710
- Product description1-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)-3-(1-METHYL-2-PHENYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-, HYDROCHLORIDE-2-PROPEN-1-ONE 95.00%
- Packaging5MG
- Price$505.04
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6096
- Product descriptionSIS3
- Packaging2mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6096
- Product descriptionSIS3
- Packaging5mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6096
- Product descriptionSIS3
- Packaging25mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5768
- Product description(E)-SIS3 >98.0%
- Packaging2mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5768
- Product description(E)-SIS3 >98.0%
- Packaging5mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5768
- Product description(E)-SIS3 >98.0%
- Packaging10mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5768
- Product description(E)-SIS3 >98.0%
- Packaging25mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00003648
- Product descriptionSIS3hydrochloride 98+%
- Packaging25mg
- Price$358
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9898
- Product descriptionSIS3 >98%
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberS0447
- Product descriptionSIS3 ≥98% (HPLC), powder
- Packaging5mg
- Price$411
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number5291
- Product descriptionSIS3 ≥98%(HPLC)
- Packaging10
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number5291
- Product descriptionSIS3 ≥98%(HPLC)
- Packaging50
- Price$1114
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberT292310
- Product description1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinolineMonohydrochloride
- Packaging1mg
- Price$95
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | INB0004710 | 1-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)-3-(1-METHYL-2-PHENYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-, HYDROCHLORIDE-2-PROPEN-1-ONE 95.00% | 5MG | $505.04 | 2021-12-16 | Buy |
| ApexBio Technology | B6096 | SIS3 | 2mg | $68 | 2021-12-16 | Buy |
| ApexBio Technology | B6096 | SIS3 | 5mg | $103 | 2021-12-16 | Buy |
| ApexBio Technology | B6096 | SIS3 | 25mg | $313 | 2021-12-16 | Buy |
| ChemScene | CS-5768 | (E)-SIS3 >98.0% | 2mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-5768 | (E)-SIS3 >98.0% | 5mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-5768 | (E)-SIS3 >98.0% | 10mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-5768 | (E)-SIS3 >98.0% | 25mg | $420 | 2021-12-16 | Buy |
| Crysdot | CD00003648 | SIS3hydrochloride 98+% | 25mg | $358 | 2021-12-16 | Buy |
| DC Chemicals | DC9898 | SIS3 >98% | 100mg | $600 | 2021-12-16 | Buy |
| Sigma-Aldrich | S0447 | SIS3 ≥98% (HPLC), powder | 5mg | $411 | 2024-03-01 | Buy |
| Tocris | 5291 | SIS3 ≥98%(HPLC) | 10 | $270 | 2021-12-16 | Buy |
| Tocris | 5291 | SIS3 ≥98%(HPLC) | 50 | $1114 | 2021-12-16 | Buy |
| TRC | T292310 | 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinolineMonohydrochloride | 1mg | $95 | 2021-12-16 | Buy |
Properties
Melting point :>161°C (dec.)
storage temp. :2-8°C
solubility :H2O: <2mg/mL
form :powder
color :yellow
InChIKey :CDKIEBFIMCSCBB-CALJPSDSSA-N
storage temp. :2-8°C
solubility :H2O: <2mg/mL
form :powder
color :yellow
InChIKey :CDKIEBFIMCSCBB-CALJPSDSSA-N
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
SIS3 hydrochloride is a specific inhibitor of Smad3 phosphorylation via inhibiting the effects of TGF-β1. Studies conducted on scleroderma fibroblasts indicate that SIS3 hydrochloride suppresses type I collagen up-regulation. In addition, SIS3 hydrochloride inhibits Smad-responsive p3TP promoter constructs activation. These studies suggest that SIS3 hydrochloride reduces DNA binding of Smad3 and that pretreatment with SIS3 hydrochloride decreases DNA binding by 50%. SIS3 hydrochloride also interferes with the interaction between contransfected Smad3 and Smad4. Furthermore, SIS3 hydrochloride reestablishes myofibroblast differentiation of scleroderma fibroblasts via reducing expression of α-SMA in these fibroblasts.More related product prices
Related product price
- SIS3
$68-1114 - 1H-Pyrrolo[2,3-b]pyridine, 2,3-dimethyl-
$45-3128
