SL 327
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- $50 - $1677
- Product name: SL 327
- CAS: 305350-87-2
- MF: C16H12F3N3S
- MW: 335.35
- EINECS:
- MDL Number:MFCD06411432
- Synonyms:ALPHA-[AMINO[(4-AMINOPHENYL)THIO]METHYLENE]-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE;ALPHA-[AMINO-(4-AMINOPHENYLTHIO)METHYLENE)-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE;SL 327;Z-EPSILON-T E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE;Z-AND E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE;a-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile;α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile;α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
30 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 1
- 10mg
- 25mg
- 50mg
- 50
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX3440
- Product descriptionSL327
- Packaging50mg
- Price$451
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1894
- Product descriptionSL-327
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0193
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0193
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- Packaging10mg
- Price$153
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0193
- Product description3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- Packaging50mg
- Price$522
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1122
- Product descriptionSL327 99%
- Packaging50mg
- Price$275
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFS101655
- Product descriptionSL 327
- Packaging10mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFS101655
- Product descriptionSL 327
- Packaging50mg
- Price$297.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15598
- Product descriptionSL 327 ≥95% (mixture of cis/trans isomers)
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15598
- Product descriptionSL 327 ≥95% (mixture of cis/trans isomers)
- Packaging5mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15598
- Product descriptionSL 327 ≥95% (mixture of cis/trans isomers)
- Packaging10mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15598
- Product descriptionSL 327 ≥95% (mixture of cis/trans isomers)
- Packaging25mg
- Price$275
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0910
- Product descriptionSL327 ≥98.0%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0910
- Product descriptionSL327 ≥98.0%
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0910
- Product descriptionSL327 ≥98.0%
- Packaging50mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002326
- Product descriptionSL327 98+%
- Packaging10mg
- Price$62
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X3440 | SL327 | 50mg | $451 | 2021-12-16 | Buy |
| ApexBio Technology | A1894 | SL-327 | 5mg | $50 | 2021-12-16 | Buy |
| Apolloscientific | BISN0193 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | 5mg | $95 | 2021-12-16 | Buy |
| Apolloscientific | BISN0193 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | 10mg | $153 | 2021-12-16 | Buy |
| Apolloscientific | BISN0193 | 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | 50mg | $522 | 2021-12-16 | Buy |
| Axon Medchem | Axon1122 | SL327 99% | 50mg | $275 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FS101655 | SL 327 | 10mg | $85 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FS101655 | SL 327 | 50mg | $297.5 | 2021-12-16 | Buy |
| Cayman Chemical | 15598 | SL 327 ≥95% (mixture of cis/trans isomers) | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 15598 | SL 327 ≥95% (mixture of cis/trans isomers) | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 15598 | SL 327 ≥95% (mixture of cis/trans isomers) | 10mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 15598 | SL 327 ≥95% (mixture of cis/trans isomers) | 25mg | $275 | 2024-03-01 | Buy |
| ChemScene | CS-0910 | SL327 ≥98.0% | 5mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-0910 | SL327 ≥98.0% | 10mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-0910 | SL327 ≥98.0% | 50mg | $360 | 2021-12-16 | Buy |
| Crysdot | CD31002326 | SL327 98+% | 10mg | $62 | 2021-12-16 | Buy |
Properties
Melting point :127-128.2 °C
Boiling point :512.6±50.0 °C(Predicted)
Density :1.40
storage temp. :2-8°C
solubility :DMSO: 32 mg/mL
form :solid
pka :3.42±0.10(Predicted)
color :white
Boiling point :512.6±50.0 °C(Predicted)
Density :1.40
storage temp. :2-8°C
solubility :DMSO: 32 mg/mL
form :solid
pka :3.42±0.10(Predicted)
color :white
Safety Information
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Description
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.More related product prices
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Suppliers and manufacturers
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$1.00 /1KG
(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile CAS:305350-87-2
(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile CAS:305350-87-2