SLx-2119
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- $49 - $1900
- Product name: SLx-2119
- CAS: 911417-87-3
- MF: C26H24N6O2
- MW: 452.51
- EINECS:
- MDL Number:MFCD23098791
- Synonyms:ROCK inhibitor 2;SLx 2119;SLx-2119;2-[3-[4-[(1H-Indazol-5-yl)amino]quinazolin-2-yl]phenoxy]-N-isopropylacetamide;KD025 (SLx-2119);SLx-2119(KD-025);KD025 (SLX-2119);SLX 2119;SLX2119;2-(3-(4-((2H-indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide
25 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 10mM(in 1mL DMSO)
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- ManufacturerAK Scientific
- Product number4050AH
- Product descriptionSLX-2119
- Packaging2mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255643
- Product description2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 99+%
- Packaging2mg
- Price$52
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255643
- Product description2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 99+%
- Packaging5mg
- Price$93
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255643
- Product description2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 99+%
- Packaging10mg
- Price$129
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255643
- Product description2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 99+%
- Packaging25mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004711
- Product description2-[3-[4-(1H-INDAZOL-5-YLAMINO)-2-QUINAZOLINYL]PHENOXY]-N-(1-METHYLETHYL)-ACETAMIDE 95.00%
- Packaging5MG
- Price$496.45
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3825
- Product descriptionSLx-2119
- Packaging10mM(in 1mL DMSO)
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3825
- Product descriptionSLx-2119
- Packaging25mg
- Price$395
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2780
- Product descriptionKD025-SLx-2119|Belumosudil 99%
- Packaging25mg
- Price$357.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17055
- Product descriptionKD 025 ≥98%
- Packaging1mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17055
- Product descriptionKD 025 ≥98%
- Packaging10mg
- Price$59
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17055
- Product descriptionKD 025 ≥98%
- Packaging25mg
- Price$140
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17055
- Product descriptionKD 025 ≥98%
- Packaging5mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17055
- Product descriptionKD025 ≥98%
- Packaging50mg
- Price$236
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17055
- Product descriptionKD025 ≥98%
- Packaging100mg
- Price$413
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM142241
- Product description2-(3-(4-((1H-indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 98%
- Packaging5g
- Price$1748
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4050AH | SLX-2119 | 2mg | $126 | 2021-12-16 | Buy |
| Ambeed | A255643 | 2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 99+% | 2mg | $52 | 2021-12-16 | Buy |
| Ambeed | A255643 | 2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 99+% | 5mg | $93 | 2021-12-16 | Buy |
| Ambeed | A255643 | 2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 99+% | 10mg | $129 | 2021-12-16 | Buy |
| Ambeed | A255643 | 2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 99+% | 25mg | $218 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004711 | 2-[3-[4-(1H-INDAZOL-5-YLAMINO)-2-QUINAZOLINYL]PHENOXY]-N-(1-METHYLETHYL)-ACETAMIDE 95.00% | 5MG | $496.45 | 2021-12-16 | Buy |
| ApexBio Technology | A3825 | SLx-2119 | 10mM(in 1mL DMSO) | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A3825 | SLx-2119 | 25mg | $395 | 2021-12-16 | Buy |
| Axon Medchem | Axon2780 | KD025-SLx-2119|Belumosudil 99% | 25mg | $357.5 | 2021-12-16 | Buy |
| Cayman Chemical | 17055 | KD 025 ≥98% | 1mg | $49 | 2021-12-16 | Buy |
| Cayman Chemical | 17055 | KD 025 ≥98% | 10mg | $59 | 2024-03-01 | Buy |
| Cayman Chemical | 17055 | KD 025 ≥98% | 25mg | $140 | 2024-03-01 | Buy |
| Cayman Chemical | 17055 | KD 025 ≥98% | 5mg | $221 | 2021-12-16 | Buy |
| Cayman Chemical | 17055 | KD025 ≥98% | 50mg | $236 | 2024-03-01 | Buy |
| Cayman Chemical | 17055 | KD025 ≥98% | 100mg | $413 | 2024-03-01 | Buy |
| Chemenu | CM142241 | 2-(3-(4-((1H-indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide 98% | 5g | $1748 | 2021-12-16 | Buy |
Properties
Melting point :>228oC (dec.)
Boiling point :682.6±55.0 °C(Predicted)
Density :1.318±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :Soluble in DMSO (25 mg/ml)
pka :13?+-.0.40(Predicted)
form :solid
color :White
Stability :Stable for 1 year as supplied from date of purchase. Solutions in DMSO may be stored at -20°C for up to 1 month.
Boiling point :682.6±55.0 °C(Predicted)
Density :1.318±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :Soluble in DMSO (25 mg/ml)
pka :13?+-.0.40(Predicted)
form :solid
color :White
Stability :Stable for 1 year as supplied from date of purchase. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Rho-associated protein kinase II (ROCK-II) regulates the formation of actin stress fibers and focal adhesions, smooth muscle contraction, and gene expression. KD 025 is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 μM, respectively). Treatment of fibrosis-derived smooth muscle cells with KD 025 (40 μM) for 24 hours reduces the expression of connective tissue growth factor and remodels actin cytoskeleton. KD 025 decreases cell-spanning F-actin fibers and increases motility of microvascular endoethelial cells. In mice, KD 025 given by oral gavage dose-dependently reduces infarct volume after transient middle cerebral artery occlusion without causing significant hypotension. In humans, oral KD 025 diminishes STAT3 phosphorylation and pro-inflammatory cytokine production in CD4+ T cells while up-regulating phosphorylation of STAT5 in regulatory T cells, altering the immune response.More related product prices
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